Human disorders associated with inflammation and the evolving role of natural products to overcome.

IVSE, isolated from Inula japonica,suppresses LPS-induced NO production via NF-κB and MAPK inactivation in RAW264.7 cells.

NO inhibitors function as potential anti-neuroinflammatory agents for AD from the flowers of Inula japonica

Bioactive sesquiterpenoids from the flowers of Inula japonica.

Inula japonica belongs to the family Asteraceae, and its flowers have been used as dietary supplements and health tea in China The study aimed to identify the bioactive components with the antiproliferative property Ten 1,10-seco-eudesmanolide derivatives, including four new compounds (1-4), were isolated from the flowers of I japonica Their structures were established on the basis of the interpretation of spectroscopic data and electronic circular dichroism (ECD) calculations All of these isolates were evaluated for their antiproliferative activities against MCF-7 and MDA-MB-231 human breast cancer cells Compound 4 possessed the most potent effects, with the IC50 values of 020 ± 004 and 622 ± 130 μM against MCF-7 and MDA-MB-231 cells, respectively The present investigation indicated that eudesmanolide derivatives from the flowers of I japonica, especially compound 4, might be used as potential antitumor chemotherapy agent candidates

Isolation, Characterization, and Antiproliferative Activities of Eudesmanolide Derivatives from the Flowers of Inula japonica.

Five new terpenes (1-5) and ten known compounds (6-15) were isolated from Inula japonica, and their structures were identified by spectroscopic analysis. Compounds 3 and 14 showed positive inhibitory effects on nitric oxide production. Furthermore, compound 14 suppressed both leukotriene C4 synthesis and degranulation in c-kit ligand-induced bone marrow-derived mast cells.

Jing-Ya Zhou

Papers

Anti-inflammatory terpenes from flowers of Inula japonica.