J
Jiyoung Oh
Researcher at University of Texas Southwestern Medical Center
Publications - 9
Citations - 163
Jiyoung Oh is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Thymic involution & Thymocyte. The author has an hindex of 6, co-authored 9 publications receiving 100 citations. Previous affiliations of Jiyoung Oh include University of North Texas Health Science Center.
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Extracellular vesicles extracted from young donor serum attenuate inflammaging via partially rejuvenating aged T-cell immunotolerance
TL;DR: The attenuation of inflammaging after treatment with EVs from young serum partially contributed to the rejuvenation of thymic aging, which is characterized by partially reversedThymic involution, enhancement of negative selection signals, and reduced autoreactions in the periphery.
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Capacity of tTreg generation is not impaired in the atrophied thymus.
TL;DR: Evidence is provided that the atrophied thymus attempts to balance the defective negative selection by enhancing tTreg cell generation to maintain central T-cell tolerance in the elderly.
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Thymic Aging May Be Associated with COVID-19 Pathophysiology in the Elderly
TL;DR: In this paper, the role of the thymus and T cells in COVID-19 immunity during aging (a synergistic effect of diminished responses to pathogens and enhanced responses to self) impacting age-related clinical severity of CoV-19 was investigated.
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Pin1-FADD interactions regulate Fas-mediated apoptosis in activated eosinophils.
Jiyoung Oh,James S. Malter +1 more
TL;DR: The data suggest that Pin1 is a critical link between FADD-mediated cell death and IL-5–mediated prosurvival signaling and in vivo–activated bronchoalveolar Eos obtained after allergen challenge showed elevated survival and Pin1 activity that could be reversed by anti-Fas.
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Thymic rejuvenation via FOXN1-reprogrammed embryonic fibroblasts (FREFs) to counteract age-related inflammation
TL;DR: In this paper, a thymic rejuvenation strategy was proposed by combining two types of promoter-driven (Rosa26CreERT and FoxN1Cre) Cre-mediated FOXN1-reprogrammed embryonic fibroblasts (Fthis papers).