J
Joan B. Christensen
Researcher at University of Michigan
Publications - 14
Citations - 1707
Joan B. Christensen is an academic researcher from University of Michigan. The author has contributed to research in topics: Antigen & DNA. The author has an hindex of 11, co-authored 14 publications receiving 1659 citations.
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Vascular Endothelial Growth Factor (VEGF)-Mediated Angiogenesis Is Associated with Enhanced Endothelial Cell Survival and Induction of Bcl-2 Expression
TL;DR: Results suggest that the angiogenic activity attributed to VEGF may be due in part to its ability to enhance endothelial cell survival by inducing expression of the anti-apoptotic protein Bcl-2.
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Engineering and characterization of functional human microvessels in immunodeficient mice
Jacques E. Nör,Martin C. Peters,Joan B. Christensen,Michelle M. Sutorik,Stephanie A. Linn,Mohamed K. Khan,Christina L. Addison,David J. Mooney,Peter J. Polverini +8 more
TL;DR: This model was used previously to demonstrate that overexpression of the antiapoptotic protein Bcl-2 in HDMEC enhances neovascularization, and that apoptotic disruption of tumor microvessels is associated with apoptosis of surrounding tumor cells.
Journal Article
Up-Regulation of Bcl-2 in microvascular endothelial cells enhances intratumoral angiogenesis and accelerates tumor growth.
Jacques E. Nör,Joan B. Christensen,Jianguo Liu,Martin C. Peters,David J. Mooney,Robert M. Strieter,Peter J. Polverini +6 more
TL;DR: It is demonstrated that the up-regulation of Bcl-2 expression in endothelial cells that constitute tumor microvessels enhances intratumoral microvascular survival and density and accelerates tumor growth.
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BK virus large T antigen: interactions with the retinoblastoma family of tumor suppressor proteins and effects on cellular growth control.
TL;DR: The experiments presented in this report show that BKV TAg can bind the tumor suppressor protein p53 and has the ability to bind to members of the retinoblastoma (pRb) family of tumor suppressing proteins both in vivo and in vitro, supporting the notion that BkV T Ag can affect cellular growth control mechanisms and may in fact be involved in neoplastic processes.
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Role for the adenovirus IVa2 protein in packaging of viral DNA.
TL;DR: Results indicate that the IVa2 protein plays a role in viral DNA packaging and that its function is serotype specific.