Joan Eilstein

TL;DR: Results obtained using PAH concentrations in the range of those reported in blood of pollution-exposed people suggest that exposure to such a photo-pollution stress, particularly if chronic, may impair cutaneous homeostasis and aggravate sunlight-induced skin damage.

TL;DR: The beneficial effects of RSV on skin are demonstrated, beyond its direct antioxidant properties, by upregulation of a cutaneous endogenous antioxidant pathway by improving of endogenous defenses induced in RSV-pretreated reconstructed skin ensured protection against the toxic oxidative effects of cumene hydroperoxide (CHP).

TL;DR: An overall assessment of the metabolic capacity from gene expression, proteomic expression, and substrate metabolism data is made and the known low expression and function of phase I enzymes in native whole skin were reflected in the in vitro models.

TL;DR: It is shown that p-benzoquinonediimines, the first oxidation derivatives of allergenic p-amino aromatic compounds, can react with nucleophilic residues on amino acids through a set of complex mechanisms and must be seriously considered as potential candidates for the formation of antigenic structures responsible for allergic contact dermatitis.

TL;DR: It is demonstrated that skin models are similar to NHS in terms of metabolic functionality toward xenobiotics investigated and useful tools to assess both the local efficiency and safety of cosmetics are used.