scispace - formally typeset
Search or ask a question

Showing papers by "Joanne M. Meyer published in 2008"

Journal Article•DOI•
Synergistic effect of apolipoprotein E ε4 and butyrylcholinesterase K-variant on progression from mild cognitive impairment to Alzheimer's disease

[...]

Roger Lane1, Howard Feldman2, Joanne M. Meyer1, Yunsheng He1, Steven H. Ferris3, Agneta Nordberg4, Taher Darreh-Shori4, Hilkka Soininen5, Tuula Pirttilä5, Martin R. Farlow, Nikolaos Sfikas1, Clive Ballard6, Nigel H. Greig •
Novartis1, University of British Columbia2, New York University3, Karolinska Institutet4, University of Eastern Finland5, King's College London6
01 Apr 2008-Pharmacogenetics and Genomics
TL;DR: In MCI, the risk of cognitive decline, hippocampal volumetric loss and progression to AD seems to be the greatest in individuals who carry at least one copy of both the BCHE-K and APOE ϵ4 alleles.
Abstract: ObjectiveTo evaluate the synergistic effects of the apolipoprotein E (APOE) e4 and butyrylcholinesterase K-variant (BCHE-K) alleles on progression to Alzheimer's disease (AD) in individuals with mild cognitive impairment (MCI).MethodsThis was a post-hoc exploratory analysis from a 3–4-year, randomiz

52 citations