J
Joffre B. Baker
Researcher at Bristol-Myers Squibb
Publications - 42
Citations - 11733
Joffre B. Baker is an academic researcher from Bristol-Myers Squibb. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 23, co-authored 41 publications receiving 11043 citations. Previous affiliations of Joffre B. Baker include University of Pittsburgh.
Papers
More filters
Journal ArticleDOI
A Multigene Assay to Predict Recurrence of Tamoxifen-Treated, Node-Negative Breast Cancer
Soonmyung Paik,Steven Shak,Gong Tang,Chungyeul Kim,Joffre B. Baker,Maureen T. Cronin,Frederick L. Baehner,Michael G. Walker,Drew Watson,Taesung Park,William Hiller,Edwin R. Fisher,D. Lawrence Wickerham,John Bryant,Norman Wolmark +14 more
TL;DR: The recurrence score has been validated as quantifying the likelihood of distant recurrence in tamoxifen-treated patients with node-negative, estrogen-receptor-positive breast cancer and could be used as a continuous function to predict distant recurrent in individual patients.
Journal ArticleDOI
Gene Expression and Benefit of Chemotherapy in Women With Node-Negative, Estrogen Receptor–Positive Breast Cancer
Soonmyung Paik,Gong Tang,Steven Shak,Chungyeul Kim,Joffre B. Baker,Wanseop Kim,Maureen T. Cronin,Frederick L. Baehner,Drew Watson,John Bryant,Joseph P. Costantino,Charles E. Geyer,D. Lawrence Wickerham,Norman Wolmark +13 more
TL;DR: The RS assay not only quantifies the likelihood of breast cancer recurrence in women with node-negative, estrogen receptor-positive breast cancer, but also predicts the magnitude of chemotherapy benefit.
Journal ArticleDOI
Gene expression profiles in paraffin-embedded core biopsy tissue predict response to chemotherapy in women with locally advanced breast cancer
Luca Gianni,Milvia Zambetti,Kim Clark,Joffre B. Baker,Maureen T. Cronin,Jenny Wu,Gabriella Mariani,Jaime Rodriguez,Marialuisa Carcangiu,Drew Watson,Pinuccia Valagussa,Roman Rouzier,W. Fraser Symmans,Jeffrey S. Ross,Gabriel N. Hortobagyi,Lajos Pusztai,Steven Shak +16 more
TL;DR: Quantitative expression of ER-related genes, proliferation genes, and immune- related genes are strong predictors of pCR in women with locally advanced breast cancer receiving neoadjuvant anthracyclines and paclitaxel, suggesting that the patients who are at greatest recurrence risk are more likely to have chemotherapy benefit.
Journal ArticleDOI
Measurement of gene expression in archival paraffin-embedded tissues: development and performance of a 92-gene reverse transcriptase-polymerase chain reaction assay.
Maureen T. Cronin,Mylan Pho,Debjani Dutta,James C. Stephans,Steven Shak,Michael C. Kiefer,Jose M. Esteban,Joffre B. Baker +7 more
TL;DR: It is shown that the extent of fragmentation of extracted FPE tissue RNA significantly increases with archive storage time, and this findings support the development of RT-PCR analysis of F PE tissue RNA as a platform for multianalyte clinical diagnostic tests.
Journal ArticleDOI
A population-based study of tumor gene expression and risk of breast cancer death among lymph node-negative patients
Laurel A. Habel,Steven Shak,Marlena K. Jacobs,Angela M. Capra,Claire Alexander,Mylan Pho,Joffre B. Baker,Michael G. Walker,Drew Watson,James Hackett,Noelle T. Blick,Deborah Greenberg,Louis Fehrenbacher,Bryan Langholz,Charles P. Quesenberry +14 more
TL;DR: In this large, population-based study of lymph node-negative patients not treated with chemotherapy, the Recurrence Score was strongly associated with risk of breast cancer death among ER-positive, tamoxifen-treated and -untreated patients.