Showing papers by "John A. McGrath published in 1990"
TL;DR: 3 Michels TC.
Abstract: 3 Michels TC. Mucocutaneous lymph node syndrome in adults, differentiation from toxic shock syndrome. AmJMed 1986; 80: 724-8. 4 Avner JR, Shaw KN, Chin AJ. Atypical presentation of Kawasaki disease with early development of giant coronary artery aneuiysms. J Pediatr 1989; 114; 605-6. 5 Leung DYM, Burns JC, Newburger JW, Geha RS. Reversal of lymphocyte activation in vivo in the Kawasaki syndrome by intravenous gamma globulin. J Clin Invest 1987; 79: 468-72.
20 citations
TL;DR: Simple, pain-free treatment in patients using EMLA® cream for excessive granulation tissue occurring in dystropbic epidermolysis bullosa, junctional epiderMolysis Bullosa (non-Herlitz form) and pyoderma gangrenosum was used and clinical results were clearly superior to similar areas treated with a topical-steroid-antibiotic combination commonly used as a standard treatment.
Abstract: SIR, A variety of ulcerating skin conditions may be complicated by tbe development of excessive granulation tissue causing a delay in ulcer bealing.' We wisb to report a new approacb to treating tbis problem using EMLA® cream (2-5% lignocaine, 2-5% prilocaine in a cream base) and 95% silver-nitrate pencils, A tbick layer (2-4 mm) of EMLA® cream is applied to tbe area of excessive granulation tissue. After about 1 b tbe area is treated witb a wetted 95% silver-nitrate pencil, A non-adbesive dressing is tben used to cover tbe treated area. No protective dressing or topical barrier is required to protect normal skin or tbe re-epitbelializing margin since tbe treated area bas a 'stiff consistency. Twenty-four bours later the dressing is removed, A crust 1-3 mm tbick can tben be peeled off quite easily in one piece, Tbe procedure is repeated again and once furtber, 24 b later, Reepitbelialization is tben able to take place mucb more satisfactorily over a flat ulcer bed. We bave used tbis simple, pain-free treatment in patients witb excessive granulation tissue occurring in dystropbic epidermolysis bullosa, junctional epidermolysis bullosa (non-Herlitz form) and pyoderma gangrenosum, Tbe clinical results were clearly superior to similar areas treated witb a topical-steroid-antibiotic combination commonly used as a standard treatment. No adverse effects sucb as patbergy or delayed bealing were observed.
10 citations
TL;DR: Levels of anti‐lipocortin‐I antibodies did not correlate with the extent or severity of cutaneous involvement, and are unlikely to be involved in the pathogenesis ofcutaneous psoriasis.
Abstract: Corticosteroids may mediate some of their anti-inflammatory effects via induction of a specific 38 kDa protein, lipocortin-I. Anti-lipocortin-I antibodies (ALA) were measured by enzyme-linked immunosorbent assay (ELISA) in 23 patients with plaque-type psoriasis alone (NAP), in 21 patients with psoriasis and arthritis (PA), and in 67 healthy controls. Only two of 23 NAP patients had elevated ALA, whereas six of 21 PA patients had raised levels of ALA (P = 0.2). Sero-negative polyarthritis was the most common pattern of joint disease in those PA patients with elevated ALA (4/6). ALA levels did not correlate with the extent or severity of cutaneous involvement, and are unlikely to be involved in the pathogenesis of cutaneous psoriasis.
8 citations