John A. Rudd

TL;DR: Findings suggest that miR-124 may work as a basilic regulating factor to alleviate cell death in the process of AD by targeting BACE1, play an essential role in the control of Bace1 gene expression, and might be considered as a novel therapeutic target in treating AD.

TL;DR: The three phthalides might have anti-cancer potential, yet the phthalide, in combination with other ingredients in Angelica sinensis extract, display significant synergy leading to a stronger anti-tumor effect.

TL;DR: The compounds isolated were evaluated for their cytotoxicity against two cancer cell lines and against normal colon cells, and the results demonstrated their selective toxicity toward the cancer cells.

TL;DR: An ability of ghrelin to reduce emesis is consistent with a role in modulating gastro-intestinal functions and identifies a novel approach to the treatment of emesis.

TL;DR: The spectrum of antiemetic effects against stimuli acting via both peripheral and centrally acting emetic stimuli, a requirement for brain penetration and blockade of emesis by microinjection of antagonists into the brain stem all support a central site of action with the nucleus tractus solitarius and the vicinity of the Botzinger complex being the favoured locations although definitive studies are awaited.