Physiological systems bioelectric phenomena biomechanics biomaterials biosensors biomedical signal analysis imaging medical instruments and devices biological effects of non-ionizing biotechnology tissue engineering human performance engineering physiological modelling, simulation and control clinical engineering and artificial intelligence. (Part contents).

The Biomedical Engineering Handbook

We survey progress over the past 25 years in the development of microscale devices for pumping fluids. We attempt to provide both a reference for micropump researchers and a resource for those outside the field who wish to identify the best micropump for a particular application. Reciprocating displacement micropumps have been the subject of extensive research in both academia and the private sector and have been produced with a wide range of actuators, valve configurations and materials. Aperiodic displacement micropumps based on mechanisms such as localized phase change have been shown to be suitable for specialized applications. Electroosmotic micropumps exhibit favorable scaling and are promising for a variety of applications requiring high flow rates and pressures. Dynamic micropumps based on electrohydrodynamic and magnetohydrodynamic effects have also been developed. Much progress has been made, but with micropumps suitable for important applications still not available, this remains a fertile area for future research.

https://microfluidics.stanford.edu/Publications/Micropumps_Cooling/Laser%20Review%20of%20Micropumps%20in%20JMM.pdf

A review of micropumps

The chemical effects of ultrasound derive primarily from acoustic cavitation. Bubble collapse in liquids results in an enormous concentration of energy from the conversion of the kinetic energy of the liquid motion into heating of the contents of the bubble. The high local temperatures and pressures, combined with extraordinarily rapid cooling, provide a unique means for driving chemical reactions under extreme conditions. A diverse set of applications of ultrasound to enhance chemical reactivity has been explored with important uses in synthetic materials chemistry. For example, the sonochemical decomposition of volatile organometallic precursors in low-volatility solvents produces nanostructured materials in various forms with high catalytic activities. Nanostructured metals, alloys, oxides, carbides and sulfides, nanometer colloids, and nanostructured supported catalysts can all be prepared by this general route. Another important application of sonochemistry in materials chemistry has been the preparation of biomaterials, most notably protein microspheres. Such microspheres have a wide range of biomedical applications, including their use in echo contrast agents for sonography, magnetic resonance imaging, contrast enhancement, and oxygen or drug delivery. Other applications include the modification of polymers and polymer surfaces.

Applications of ultrasound to materials chemistry

Entropy generation minimization (finite time thermodynamics, or thermodynamic optimization) is the method that combines into simple models the most basic concepts of heat transfer, fluid mechanics, and thermodynamics. These simple models are used in the optimization of real (irreversible) devices and processes, subject to finite‐size and finite‐time constraints. The review traces the development and adoption of the method in several sectors of mainstream thermal engineering and science: cryogenics, heat transfer, education, storage systems, solar power plants, nuclear and fossil power plants, and refrigerators. Emphasis is placed on the fundamental and technological importance of the optimization method and its results, the pedagogical merits of the method, and the chronological development of the field.

Entropy generation minimization: The new thermodynamics of finite-size devices and finite-time processes

Recent advances in nanostructured materials have been led by the development of new synthetic methods that provide control over size, morphology, and nano/microstructure. The utilization of high intensity ultrasound offers a facile, versatile synthetic tool for nanostructured materials that are often unavailable by conventional methods. The primary physical phenomena associated with ultrasound that are relevant to materials synthesis are cavitation and nebulization. Acoustic cavitation (the formation, growth, and implosive collapse of bubbles in a liquid) creates extreme conditions inside the collapsing bubble and serves as the origin of most sonochemical phenomena in liquids or liquid-solid slurries. Nebulization (the creation of mist from ultrasound passing through a liquid and impinging on a liquid-gas interface) is the basis for ultrasonic spray pyrolysis (USP) with subsequent reactions occurring in the heated droplets of the mist. In both cases, we have examples of phase-separated attoliter microreactors: for sonochemistry, it is a hot gas inside bubbles isolated from one another in a liquid, while for USP it is hot droplets isolated from one another in a gas. Cavitation-induced sonochemistry provides a unique interaction between energy and matter, with hot spots inside the bubbles of approximately 5000 K, pressures of approximately 1000 bar, heating and cooling rates of >10(10) K s(-1); these extraordinary conditions permit access to a range of chemical reaction space normally not accessible, which allows for the synthesis of a wide variety of unusual nanostructured materials. Complementary to cavitational chemistry, the microdroplet reactors created by USP facilitate the formation of a wide range of nanocomposites. In this review, we summarize the fundamental principles of both synthetic methods and recent development in the applications of ultrasound in nanostructured materials synthesis.

Applications of Ultrasound to the Synthesis of Nanostructured Materials

An experimental study of heat transfer and flow regimes during condensation of refrigerants in horizontal tubes was conducted. Measurements were made in smooth, round tubes with diameters ranging from 3.14 mm to 7.04 mm. The refrigerants tested were R-12, R-22, R-134a, and near-azeotropic blends of R-32/R-125 in 50 percent/50 percent and 60 percent/40 percent compositions. The study focused primarily on measurement and prediction of condensing heat transfer coefficients and the relationship between heat transfer coefficients and two-phase flow regimes. Flow regimes were observed visually at the inlet and outlet of the test condenser as the heat transfer data were collected. Stratified, wavy, wavy annular, annular, annular mist, and slug flows were observed. True mist flow without a stable wall film was not observed during condensation tests. The experimental results were compared with existing flow regime maps and some corrections are suggested. The heat transfer behavior was controlled by the prevailing flow regime. For the purpose of analyzing condensing heat transfer behavior, the various flow regimes were divided into two broad categories of gravity-dominated and shear-dominated flows. In the gravity dominated flow regime, the dominant heat transfer mode was laminar film condensation in the top of the tube. This regime was characterized by heat transfer coefficients that depended on the wall-to-refrigerant temperature difference but were nearly independent of mass flux. In the shear-dominated flow regime, forced-convective condensation was the dominant heat transfer mechanism. This regime was characterized by heat transfer coefficients that were independent of temperature difference but very dependent on mass flux and quality. Heat transfer correlations that were developed for each of these flow regimes successfully predicted data from the present study and from several other sources.

Condensation in Smooth Horizontal Tubes

Heat transfer to individual blood vessels has been investigated in three configurations: a single vessel, two vessels in counterflow, and a single vessel near the skin surface. For a single vessel the Graetz number is the controlling parameter. The arterioles, capillaries, and venules have very low Graetz numbers, Gz < 0.4, and act as perfect heat exchangers in which the blood quickly reaches the tissue temperature. The large arteries and veins with Graetz numbers over 10(3) have virtually no heat exchange with the tissue, and blood leaves them at near the entering temperature. Heat transfer between parallel vessels in counterflow is influenced most strongly by the relative distance of separation anad by the mass transferred from the artery to the vein along the length. These two effects are of the same order of magnitude, whereas the film coefficients in the blood flow are of significant but lesser importance. The effect of a blood vessel on the temperature distribution of the skin directly above it and on the heat transfer to the environment increases with decreasing depth-to-radius ratio and decreasing Biot number based on radius. The absolute magnitude of these effects is independent of other linear effects, such as internal heat generation or a superimposed one-dimensional heat flux.

Heat transfer to blood vessels

The ultimate flow rate and velocity of an electrohydrodynamic (EHD) pump with a given length and depth are determined by the material properties of the working fluid. High dielectric constant, and low viscosity lead to high flow velocities, while low conductivity and mobility promote high efficiency. A fundamental model of EHD pumping is formulated to account for the material properties of the working fluid, and is applied to several experimental pumps reported earlier, with generally good agreement. An example of the use of this model to select a working fluid for a typical pump suggests several new liquids suitable for EHD pumping. >

Selecting a working fluid to increase the efficiency and flow rate of an EHD pump

Horizontal smooth and microfinned copper tubes with an approximate diameter of 9 mm were successively flattened in order to determine changes in flow field characteristics as a round tube is altered into a flattened tube profile. Refrigerants R134a and R410A were investigated over a mass flux range from 75 to 400 kg m−2 s−1 and a quality range from approximately 10–80%. For a given refrigerant mass flow rate, the results show that a significant reduction in refrigerant charge is possible. Pressure drop results show increases of pressure drop at a given mass flux and quality as a tube profile is flattened. Heat transfer results indicate enhancement of the condensation heat transfer coefficient as a tube is flattened. Flattened tubes with an 18° helix angle displayed the highest heat transfer coefficients. Smooth tubes and axial microfin tubes displayed similar levels of heat transfer enhancement. Heat transfer enhancement is dependent on the mass flux, quality and tube profile.

/pdf/refrigerant-charge-pressure-drop-and-condensation-heat-4jqlkmyxl4.pdf

Refrigerant charge, pressure drop, and condensation heat transfer in flattened tubes

A series of experiments to determine void fraction in both condensation and evaporation have been performed in horizontal microfin tubes with refrigerants R134a and R410A. Mass flux varied from 75 kg/m2·s to 700 kg/m2·s and average test section quality varied from 5% to 80%. Zero degree (axial grooving) and 18 degree helix microfin tube configurations have been examined in both condensation and evaporation. Four tubes were examined (7.3 mm and 8.9 mm diameters with axial and 18 degree helix angle microfins). Evaporation and adiabatic conditions in microfin tubes generally show similar void fraction trends found in smooth tubes. Condensation results for microfin tubes show a lower void fraction than smooth tubes.

/pdf/an-investigation-of-refrigerant-void-fraction-in-horizontal-2wdt5uze8x.pdf

John C. Chato

Papers

Condensation in Smooth Horizontal Tubes

Heat transfer to blood vessels

Selecting a working fluid to increase the efficiency and flow rate of an EHD pump

Refrigerant charge, pressure drop, and condensation heat transfer in flattened tubes

An Investigation of Refrigerant Void Fraction in Horizontal, Microfin Tubes