Showing papers by "John E. Christian published in 1950"
10 citations
TL;DR: In this paper, the absorption of sodium ion in the rat has been studied after introduction into the gastrointestinal tract and after subcutaneous injection using radioactive sodium-24 and 22 labeled NaCl.
Abstract: The absorption of sodium ion in the rat has been studied after introduction into the gastrointestinal tract and after subcutaneous injection using radioactive sodium-24 and 22 labeled NaCl. By these methods the effect of various osmotic pressures, various pH's, and of certain astringent materials on normal absorption from these areas was determined.
6 citations
TL;DR: Sulfur-35 was found to be relatively uniformly distributed in the animal body at one, two, four, eight, and twenty-four hours after administration of labeled sulfanilamide.
Abstract: Sulfur-35 was found to be relatively uniformly distributed in the animal body at one, two, four, eight, and twenty-four hours after administration of labeled sulfanilamide. The same was true two hours after the last of 16–18 doses at four-hour intervals. The tissues concerned with excretion and detoxification tended to show, particularly at the later time intervals, concentrations slightly higher than the other tissues. There is no evidence of extensive binding of sulfanilamide by the tissues.
4 citations
4 citations
TL;DR: An in vivo method for testing enteric coatings is described which involves coating small pills containing radiosodium, administering them to a rat, and determining the time of disintegration by the appearance of radiosodium in the circulation and the site of disintegation by direct observation of the gastrointestinal tract.
Abstract: An in vivo method for testing enteric coatings is described which involves coating small pills containing radiosodium, administering them to a rat, and determining the time of disintegration by the appearance of radiosodium in the circulation and the site of disintegration by direct observation of the gastrointestinal tract. The results of the method have been compared to the results of an in vitro method.
1 citations
TL;DR: The marked hypnotic activity of numerous aliphatic derivatives of methionic acid suggested the synthesis of aromatic and heterocyclic amides of methionics acid as compounds of possible medicinal value, and twenty-two new such derivatives have been prepared.
Abstract: The marked hypnotic activity of numerous aliphatic derivatives of methionic acid suggested the synthesis of aromatic and heterocyclic amides of methionic acid as compounds of possible medicinal value. The occurrences of the pyridine, pyrimidine, and thiazole nuclei in active antibacterial compounds, the use of quinoline derivatives as antimalarials, and the bacteriostatic property of compounds such as p-aminoacetophenone and p-aminobenzophenone have had a direct bearing on the choice of some of the compounds synthesized. Twenty-two new such derivatives of methionic acid have been prepared and sufficient quantities have been prepared for bacteriological and pharmacological testing.