What is modal logic

General Topology-I

Proceedings of the American Mathematical Society

In this paper, we review the definition and basic properties of the different types of fuzzy sets that have appeared up to now in the literature. We also analyze the relationships between them and enumerate some of the applications in which they have been used.

/pdf/a-historical-account-of-types-of-fuzzy-sets-and-their-jtvbgqsyj5.pdf

A Historical Account of Types of Fuzzy Sets and Their Relationships

https://escholarship.org/content/qt1f24g5vf/qt1f24g5vf.pdf?t=qcdjff

Cardiac Repair in a Porcine Model of Acute Myocardial Infarction with Human Induced Pluripotent Stem Cell-Derived Cardiovascular Cells

Bounded Lattice Expansions

The field of regenerative medicine is approaching translation to clinical practice, and significant safety concerns and knowledge gaps have become clear as clinical practitioners are considering the potential risks and benefits of cell-based therapy. It is necessary to understand the full spectrum of stem cell actions and preclinical evidence for safety and therapeutic efficacy. The role of animal models for gaining this information has increased substantially. There is an urgent need for novel animal models to expand the range of current studies, most of which have been conducted in rodents. Extant models are providing important information but have limitations for a variety of disease categories and can have different size and physiology relative to humans. These differences can preclude the ability to reproduce the results of animal-based preclinical studies in human trials. Larger animal species, such as rabbits, dogs, pigs, sheep, goats, and non-human primates, are better predictors of responses in humans than are rodents, but in each case it will be necessary to choose the best model for a specific application. There is a wide spectrum of potential stem cell-based products that can be used for regenerative medicine, including embryonic and induced pluripotent stem cells, somatic stem cells, and differentiated cellular progeny. The state of knowledge and availability of these cells from large animals vary among species. In most cases, significant effort is required for establishing and characterizing cell lines, comparing behavior to human analogs, and testing potential applications. Stem cell-based therapies present significant safety challenges, which cannot be addressed by traditional procedures and require the development of new protocols and test systems, for which the rigorous use of larger animal species more closely resembling human behavior will be required. In this article, we discuss the current status and challenges of and several major directions for the future development of large animal models to facilitate advances in stem cell-based regenerative medicine.

/pdf/large-animal-models-for-stem-cell-therapy-19j32s546e.pdf

Large animal models for stem cell therapy

Systems and methods provide for on-the-fly adaptation of a send rate for content sent to a client based on a detected read rate of the client system for data previously sent. The system and method work within the bounds of simple, existing, open protocols and the media files served are playable by standard media playback clients. The method is driven by a request for media content from a client, in response to which the server provides portions of the media content and monitors the reception rate of the content as it is sent to the client. This method allows for dynamic modification of the send rate of the content after the server has calculated an adjustment to correct for the difference between the reading rate and sending rate, thereby allowing for a send rate most compatible with the client.

Media article adaptation to client device

Systems and methods provide for dynamic generation of media content at the point that content is served. The system and method work within the bounds of simple, existing, open protocols and the media files served are playable by standard media playback clients. The method is driven by a request for media content from a client specifying an edit list. The server opens one or more source files and selects portions of one or more files to transmit based on edit list instructions, and sequentially writes those portions to an output for serving to the client. The method allows for various modifications of the content before serving.

Dynamic media serving infrastructure

Systems and methods provide for dynamic generation of media content at the point that content is served. The system and method work within the bounds of simple, existing, open protocols and the media files served are playable by standard media playback clients. The method is driven by a request for media content from a client specifying an edit list. The server opens one or more source files and selects portions of one or more files to transmit based on edit list instructions, and sequentially writes those portions to an output for serving to the client. The server sorts the selected portions of one or more source media files, combines the selected portions to form a combined media shot, and serves the combined media shot to the client. The method allows for various modifications of the content before serving.

John Harding

Papers

Bounded Lattice Expansions

Large animal models for stem cell therapy

Media article adaptation to client device

Dynamic media serving infrastructure

Combining and serving media content