J
John M. Skibber
Researcher at National Institutes of Health
Publications - 35
Citations - 3818
John M. Skibber is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Colorectal cancer & Cancer. The author has an hindex of 16, co-authored 35 publications receiving 3685 citations.
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Journal ArticleDOI
Observations on the Systemic Administration of Autologous Lymphokine-Activated Killer Cells and Recombinant Interleukin-2 to Patients with Metastatic Cancer
Steven A. Rosenberg,Michael T. Lotze,Linda M. Muul,Susan F. Leitman,Alfred E. Chang,S. E. Ettinghausen,Yvedt L. Matory,John M. Skibber,Eitan Shiloni,John T. Vetto,Claudia A. Seipp,Colleen Simpson,Cheryl M. Reichert +12 more
TL;DR: Preliminary results of the systemic administration of autologous lymphokine-activated killer (LAK) cells and the recombinant-derived lymphokin interleukin-2 to patients with advanced cancer are described, based on animal models in which this regimen mediated the regression of established pulmonary and hepatic metastases from a variety of murine tumors in several strains of mice.
Journal ArticleDOI
Cardiorespiratory effects of immunotherapy with interleukin-2.
R E Lee,Michael T. Lotze,John M. Skibber,Eben Tucker,Robert O. Bonow,Frederick P. Ognibene,Jorge A. Carrasquillo,James H. Shelhamer,Joseph E. Parrillo,Steven A. Rosenberg +9 more
TL;DR: Patients with underlying cardiorespiratory diseases may be at greater risk during IL-2 administration and should not be selected to undergo this treatment.
Journal ArticleDOI
Interleukin-2 Administration Causes Reversible Hemodynamic Changes and Left Ventricular Dysfunction Similar to Those Seen in Septic Shock
Frederick P. Ognibene,Steven A. Rosenberg,Michael T. Lotze,John M. Skibber,Margaret M. Parker,James H. Shelhamer,Joseph E. Parrillo +6 more
TL;DR: Interleukin-2 induces multiple reversible cardiovascular abnormalities that are similar to the hemodynamic manifestations of human septic shock.
Journal ArticleDOI
Right lower quadrant pain in young patients with leukemia. A surgical perspective.
TL;DR: In this article, a retrospective review of cecal and appendiceal complications occurring in young patients with acute leukemia since 1969 was performed, and the relative incidence of appendicitis and typhlitis among patients who had operation or autopsy in this institution as well as to determine the risks of operative intervention.
Journal ArticleDOI
Are We Undertreating Rectal Cancer in the Elderly?: An Epidemiologic Study
TL;DR: In elderly patients, rectal cancer is characterized by decreased cancer-related survival rates that are associated with less aggressive treatment overall and decreased disease stages at presentation.