Early and locally advanced non-small-cell lung cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

Treatment of stage I and II non-small cell lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines.

Automated Identification of Diabetic Retinopathy Using Deep Learning

Physiologic evaluation of the patient with lung cancer being considered for resectional surgery: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines.

A collaboration of multidisciplinary experts on the functional evaluation of lung cancer patients has been facilitated by the European Respiratory Society (ERS) and the European Society of Thoracic Surgery (ESTS), in order to draw up recommendations and provide clinicians with clear, up-to-date guidelines on fitness for surgery and chemo-radiotherapy. The subject was divided into different topics, which were then assigned to at least two experts. The authors searched the literature according to their own strategies, with no central literature review being performed. The draft reports written by the experts on each topic were reviewed, discussed and voted on by the entire expert panel. The evidence supporting each recommendation was summarised, and graded as described by the Scottish Intercollegiate Guidelines Network Grading Review Group. Clinical practice guidelines were generated and finalized in a functional algorithm for risk stratification of the lung resection candidates, emphasising cardiological evaluation, forced expiratory volume in 1 s, systematic carbon monoxide lung diffusion capacity and exercise testing. Contrary to lung resection, for which the scientific evidences are more robust, we were unable to recommend any specific test, cut-off value, or algorithm before chemo-radiotherapy due to the lack of data. We recommend that lung cancer patients should be managed in specialised settings by multidisciplinary teams.

https://erj.ersjournals.com/content/erj/34/1/17.full.pdf

ERS/ESTS clinical guidelines on fitness for radical therapy in lung cancer patients (surgery and chemo-radiotherapy)

A joint initiative by the British Thoracic Society and the Society for Cardiothoracic Surgery in Great Britain and Ireland was undertaken to update the 2001 guidelines for the selection and assessment of patients with lung cancer who can potentially be managed by radical treatment.

https://thorax.bmj.com/content/thoraxjnl/65/Suppl_3/iii1.full.pdf

Guidelines on the radical management of patients with lung cancer

These guidelines have been replaced by BTS Pleural Disease Guideline 2010 Superseded By BTS Pleural Disease Guideline 2010: BTS Guidelines for the Management of Pleural Disease. Thorax 2003 May; 58(Suppl 2): 1–59.

BTS guidelines for the insertion of a chest drain

Objective: To determine whether patient gender affects the outlook following lung resection for non-small cell lung cancer (NSCLC). Patients and methods: Prospectively collected data on 833 patients undergoing lung resection for NSCLC between 1990 and 2000 in a single unit were analysed. Results: 581 patients were male (mean age 64.7 ^ 7 years) and 252 were female (mean age 62.6 ^ 7.8 years) ðP ¼ 0:006Þ. Male patients were more likely to have a history of ischaemic heart disease ðP ¼ 0:03Þ, to have poorer preoperative spirometry as demonstrated by their % predicted FEV1 ðP ¼ 0:02Þ and to need pneumonectomy ðP ¼ 0:0001Þ than their female counterparts. Squamous cell carcinoma was the predominant histological cell type in men and adenocarcinoma in women ðP , 0:0001Þ. There was a trend towards a lower pathological stage among women, but this was not significant. Operative mortality for men was 4.6 and 1.2% for women ðP ¼ 0:01Þ. Overall 5-year survival for men was 34.2 ^ 2.65% and 47.5 ^ 4.2% for women ðP ¼ 0:001Þ and, for the hospital survivors, was 36.5 ^ 2.7% and 48.1 ^ 4.2%, respectively ðP ¼ 0:01Þ. On univariate analysis, older age, the need for pneumonectomy and higher pathological stage were significant adverse factors whereas squamous cell type and female gender were significant favourable factors for survival ðP , 0:05Þ. On Cox proportional hazards model (with and without hospital deaths), pathological stage ðP , 0:0001Þ, female gender ðP ¼ 0:0006Þ and squamous cell type ðP ¼ 0:001Þ were independent predictors of survival. The survival was significantly better for women having squamous cell ðP ¼ 0:01Þ or non-squamous cell cancers (adenocarcinoma and other) ðP ¼ 0:002Þ. Regarding the stage, women had a significant survival advantage at pathological stage I ðP ¼ 0:01Þ and a relatively better survival at stage II and stage III disease ðP ¼ 0:3Þ. Conclusions: This study suggests that female gender exerts a significant positive effect on survival following lung resection for NSCLC. This effect is pronounced at early disease stage and persists after adjusting for important differences in the clinical, histo-pathological features and extent of pulmonary resection between male and female patients. q 2002 Elsevier Science B.V. All rights reserved.

Do women live longer following lung resection for carcinoma

https://www.annalsthoracicsurgery.org/article/S0003-4975(03)00883-X/pdf

John P. Duffy

Papers

Guidelines on the radical management of patients with lung cancer

BTS guidelines for the insertion of a chest drain

Do women live longer following lung resection for carcinoma

Pneumonectomy for stage I (T1N0 and T2N0) nonsmall cell lung cancer has potent, adverse impact on survival.

Esophagectomy for cancer in the patient aged 70 years and older