J
John R. Mantsch
Researcher at Marquette University
Publications - 65
Citations - 3561
John R. Mantsch is an academic researcher from Marquette University. The author has contributed to research in topics: Self-administration & Nucleus accumbens. The author has an hindex of 34, co-authored 59 publications receiving 3126 citations. Previous affiliations of John R. Mantsch include Louisiana State University & Rockefeller University.
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Stress-Induced Reinstatement of Drug Seeking: 20 Years of Progress.
TL;DR: The phenomenon of stress-induced reinstatement, first shown with an intermittent footshock stressor in rats trained to self-administer heroin, generalizes to other abused drugs, including cocaine, methamphetamine, nicotine, and alcohol, and is also observed in the conditioned place preference model in rats and mice.
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Repeated N-Acetylcysteine Administration Alters Plasticity-Dependent Effects of Cocaine
Aric Madayag,Doug Lobner,Kristen S. Kau,John R. Mantsch,Omer Abdulhameed,Matthew C. Hearing,Mark D. Grier,David A. Baker +7 more
TL;DR: Findings indicate that N-acetylcysteine selectively alters plasticity-dependent behaviors and that normal system xc− activity prevents pathological changes in extracellular glutamate that may be necessary for compulsive drug seeking.
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Effects of extended access to high versus low cocaine doses on self-administration, cocaine-induced reinstatement and brain mRNA levels in rats.
John R. Mantsch,John R. Mantsch,Vadim Yuferov,Anne-Marie Mathieu-Kia,Ann Ho,Mary Jeanne Kreek +5 more
TL;DR: The escalation of cocaine SA under LgA conditions is dose-dependent and is associated with heightened susceptibility to drug-induced relapse, and the characterization of neurobiological alterations that accompany escalated SA should facilitate the identification of mechanisms underlying the onset of human addiction.
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Predictable individual differences in the initiation of cocaine self-administration by rats under extended-access conditions are dose-dependent.
TL;DR: The present findings indicate that predictable individual differences in cocaine SA under extended access conditions are relevant only at low doses and are surmountable by increasing the available dose of cocaine.
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Repeated N -Acetyl Cysteine Reduces Cocaine Seeking in Rodents and Craving in Cocaine-Dependent Humans
Shelley L. Amen,Linda B. Piacentine,Muhammad E Ahmad,Shi-Jiang Li,John R. Mantsch,Robert C. Risinger,David A. Baker +6 more
TL;DR: It is demonstrated that N-acetyl cysteine diminishes the motivational qualities of a cocaine challenge injection possibly by altering pathogenic drug-induced plasticity.