J
John Romer
Researcher at University of California, San Francisco
Publications - 3
Citations - 542
John Romer is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Matrix metalloproteinase & Mammary gland involution. The author has an hindex of 2, co-authored 3 publications receiving 521 citations.
Papers
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Journal ArticleDOI
Two distinct phases of apoptosis in mammary gland involution: proteinase-independent and -dependent pathways.
Leif R. Lund,John Romer,Nicole Thomasset,Helene Solberg,Charles Pyke,Mina J. Bissell,Keld Danø,Zena Werb +7 more
TL;DR: The data support the hypothesis that there are at least two distinct phases of involution: an initial phase, characterized by induction of the apoptosis-associated genes SGP-2 and ICE and apoptosis of fully differentiated mammary epithelial cells without visible degradation of the extracellular matrix, and a second phase, characterize by extrace cellular matrix remodeling and altered mesenchymal-epithelial interactions, followed by apoptotic cells that are losing differentiated functions.
Patent
Suppression of inhibitors
Nils Brunner,John Romer,Vincent Ellis,Charles Pyke,Jan Grøndahl-Hansen,Helle Pedersen,Heine H. Hansen,Keld Dano +7 more
TL;DR: In this paper, a method for suppressing the inhibitory activity of an inhibitor of a protease or of a non-proteolytic matrix-degrading enzyme (IPNME) in malignant tumour tissue was proposed.
Book ChapterDOI
The Plasminogen Activation System in Tissue Remodeling and Cancer Invasion
TL;DR: It is anticipated that similar functional redundancies are widespread in physiological as well as pathological proteolytic processes, and it therefore represents a challenge to identify the critical proteases for therapeutic targeting.