J
John T. Woosley
Researcher at University of North Carolina at Chapel Hill
Publications - 225
Citations - 10035
John T. Woosley is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Eosinophilic esophagitis & Magnetic resonance imaging. The author has an hindex of 55, co-authored 217 publications receiving 8742 citations.
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Proceedings ArticleDOI
A method for normalizing histology slides for quantitative analysis
Marc Macenko,Marc Niethammer,James Stephen Marron,David Borland,John T. Woosley,Xiaojun Guan,Charles Schmitt,Nancy E. Thomas +7 more
TL;DR: This paper provides two mechanisms for overcoming many of the known inconsistencies in the staining process, thereby bringing slides that were processed or stored under very different conditions into a common, normalized space to enable improved quantitative analysis.
Journal ArticleDOI
A phenotypic analysis shows that eosinophilic esophagitis is a progressive fibrostenotic disease
Evan S. Dellon,Hannah P. Kim,Sarah L.W. Sperry,David A. Rybnicek,John T. Woosley,Nicholas J. Shaheen +5 more
TL;DR: In this large EoE cohort, the likelihood of fibrostenotic disease increased markedly with age, and this association suggests that the natural history of Eosinophilic esophagitis is a progression from an inflammatory to a fibrostanotic disease.
Journal ArticleDOI
Clinical, endoscopic, and histologic findings distinguish eosinophilic esophagitis from gastroesophageal reflux disease
Evan S. Dellon,Wood B. Gibbs,Karen J. Fritchie,Tara C. Rubinas,Lindsay A. Wilson,John T. Woosley,Nicholas J. Shaheen +6 more
TL;DR: A set of readily available and routinely measured variables that differentiate EoE from GERD are identified and use of this type of analysis with patients suspected to have EiE might lead to more accurate diagnoses.
Journal ArticleDOI
Circulating levels of inflammatory cytokines and risk of colorectal adenomas.
Sangmi Kim,Temitope O. Keku,Christopher Martin,Joseph A. Galanko,John T. Woosley,Jane C. Schroeder,Jessie A. Satia,Susan Halabi,Robert S. Sandler +8 more
TL;DR: The prevalence of colorectal adenomas was associated with higher concentrations of IL-6 and TNF-alpha and, to a lesser degree, with CRP, which indicates that systemic inflammation might be involved in the early development of colOREctal neoplasia.
Journal ArticleDOI
Viscous Topical Is More Effective Than Nebulized Steroid Therapy for Patients With Eosinophilic Esophagitis
Evan S. Dellon,Arif Sheikh,Olga Speck,Kimberly Woodward,Ann Whitlow,Jessica Hores,Marija Ivanovic,Allen Chau,John T. Woosley,Ryan D. Madanick,Roy C. Orlando,Nicholas J. Shaheen +11 more
TL;DR: OVB was more effective than NEB in reducing numbers of esophageal eosinophils in patients with EoE and provided a significantly higher level of esphageal exposure to the therapeutic agent, which correlated with lower eOSinophil counts.