John W. Earl

TL;DR: Cerebrospinal fluid neopterin production is increased by interferon‐gamma stimulation and appears to act as a marker of intrathecal immune activation and may be a biological marker of central nervous system (CNS) inflammation.

TL;DR: The model has been evaluated and can be used in the design of rational dosing strategies for L-AmB antifungal therapy in this special population of pediatric patients with malignant diseases.

TL;DR: Two neonates presenting with perinatal hypophosphatasia and severe epileptic encephalopathy resulting in death had increased levels of urinary vanillactate, indicating functional deficiency of aromatic amino acid decarboxylase, a pyridoxal-5-phosphate (PLP)-dependent enzyme required for dopamine and serotonin biosynthesis.

TL;DR: Creatinine clearance, fat free mass and haematocrit influence total and unboundmelphalan plasma clearance, andMelphalan exposure is related to melphalan toxicity while the association with efficacy shows promising trends that will be studied further.

TL;DR: The findings suggest that MOG Ab POS patients have a more pronounced CNS inflammatory response with elevation of predominant humoral associated cytokines/chemokines, as well as some Th 17 and neutrophil related cytokines and chemokines suggesting a differential inflammatory pathogenesis associated with MOG antibody seropositivity.