J
John Walker
Researcher at University College London
Publications - 89
Citations - 6431
John Walker is an academic researcher from University College London. The author has contributed to research in topics: Heart failure & Ejection fraction. The author has an hindex of 31, co-authored 87 publications receiving 6147 citations. Previous affiliations of John Walker include University College London Hospitals NHS Foundation Trust & University College Hospital.
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Journal ArticleDOI
Cardiovascular T2-star (T2*) magnetic resonance for the early diagnosis of myocardial iron overload
Lisa J. Anderson,S Holden,Bernard A. Davis,Emma Prescott,CC Charrier,N Bunce,David N. Firmin,Beatrix Wonke,John B. Porter,John Walker,Dudley J. Pennell +10 more
TL;DR: Myocardial iron deposition can be reproducibly quantified using myocardial T2* and this is the most significant variable for predicting the need for ventricular dysfunction treatment, and early intensification of iron chelation therapy should reduce mortality from this reversible cardiomyopathy.
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Cardiac stress protein elevation 24 hours after brief ischemia or heat stress is associated with resistance to myocardial infarction.
TL;DR: It is suggested that stress protein elevation, rather than the nonspecific effects of thermal or ischemic stress, may be responsible for the myocardial protection seen in this model.
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Cardiac T2* Magnetic Resonance for Prediction of Cardiac Complications in Thalassemia Major
Paul D. W. Kirk,M Roughton,John B. Porter,John Walker,Mark Tanner,Junaid Patel,D. Wu,J. Taylor,Mark Westwood,Lisa J. Anderson,Dudley J. Pennell +10 more
TL;DR: Cardiac T2* magnetic resonance identifies patients at high risk of heart failure and arrhythmia from myocardial siderosis in thalassemia major and is superior to serum ferritin and liver iron.
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A Randomized, Placebo-Controlled, Double-Blind Trial of the Effect of Combined Therapy With Deferoxamine and Deferiprone on Myocardial Iron in Thalassemia Major Using Cardiovascular Magnetic Resonance
Mark A. Tanner,Renzo Galanello,Carlo Dessì,Gillian C. Smith,Mark Westwood,Annalisa Agus,M Roughton,Ravi Assomull,Sunil V. Nair,John Walker,Dudley J. Pennell +10 more
TL;DR: In comparison to the standard chelation monotherapy of deferoxamine, combination treatment with additional deferiprone reduced myocardial iron and improved the ejection fraction and endothelial function in thalassemia major patients with mild to moderate cardiac iron loading.
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Cardiovascular Function and Treatment in β-Thalassemia Major: A Consensus Statement From the American Heart Association
Dudley J. Pennell,James E. Udelson,Andrew E. Arai,Biykem Bozkurt,Alan R. Cohen,Renzo Galanello,Timothy M. Hoffman,Michael S. Kiernan,Stamatios Lerakis,Antonio Piga,John B. Porter,John Walker,John C. Wood +12 more
TL;DR: In this article, the authors report an expert consensus on the diagnosis and treatment of cardiac dysfunction in β-thalassemia major (TM), which does not cover other hemoglobias.