Showing papers by "John Yarnell published in 1997"
TL;DR: The main contributor to the increase in total count in the men who developed disease was the neutrophil count, and there was also a statistically significant increase in the eosinophil count.
Abstract: A number of studies have shown total leukocyte count to be a risk factor for ischemic heart disease, but there is little information on the role of the individual types of leukocyte, and the role of smoking is controversial. The Caerphilly and Speedwell studies recruited 4,860 men aged 45-63 years between 1979 and 1983 in South Wales and the West of England, respectively. At the 10-year follow-up, the total leukocyte count predicted ischemic heart disease events after adjusting for the classical risk factors, including smoking. Five-year follow-up results were available for differential white cell counts. The main contributor to the increase in total count in the men who developed disease was the neutrophil count. There was also a statistically significant increase in the eosinophil count.
199 citations
01 Mar 1997
TL;DR: The present review focuses on two novel risk factors: hyperhomocysteinaemia and LDL oxidation, which can be linked with inadequate vitamin intake and, therefore, may be amenable to nutritional intervention.
Abstract: CHD causes approximately half the deaths among middle-aged adults in the industrialized world. However, major accepted risk factors combined can explain only about 50% of heart disease (Editorial, 1984). The possible aetiological involvement of novel risk factors, therefore, is receiving much attention. The present review focuses on two such risk factors: hyperhomocysteinaemia and LDL oxidation. Both these factors can be linked with inadequate vitamin intake and, therefore, may be amenable to nutritional intervention (Selhub et al. 1993; Jha et a1. 1995).
9 citations