J
Jon W. Weeks
Researcher at University of Oklahoma
Publications - 14
Citations - 409
Jon W. Weeks is an academic researcher from University of Oklahoma. The author has contributed to research in topics: Bacterial outer membrane & Efflux. The author has an hindex of 7, co-authored 11 publications receiving 313 citations.
Papers
More filters
Journal ArticleDOI
Synergy between Active Efflux and Outer Membrane Diffusion Defines Rules of Antibiotic Permeation into Gram-Negative Bacteria.
Ganesh Krishnamoorthy,Inga V. Leus,Jon W. Weeks,David Wolloscheck,Valentin V. Rybenkov,Helen I. Zgurskaya +5 more
TL;DR: It is found that the outer membrane (OM) and efflux pumps select compounds on the basis of distinct properties and together universally protect bacteria from structurally diverse antibiotics.
Journal ArticleDOI
Breaking the Permeability Barrier of Escherichia coli by Controlled Hyperporination of the Outer Membrane.
Ganesh Krishnamoorthy,David Wolloscheck,Jon W. Weeks,Cameron Croft,Valentin V. Rybenkov,Helen I. Zgurskaya +5 more
TL;DR: The results identify antibiotics which are the best candidates for the potentiation of activities through efflux inhibition and permeabilization of the outer membrane.
Journal ArticleDOI
Substrate Specificities and Efflux Efficiencies of RND Efflux Pumps of Acinetobacter baumannii
TL;DR: Approximate levels of antibiotic resistance in A. baumannii isolates are unlikely to be reached solely due to the overproduction of RND efflux pumps, and the impact of efflux pump overproduction on antibiotic susceptibility is significantly lower than the previously reported for clinical isolates.
Journal ArticleDOI
Mechanism of coupling drug transport reactions located in two different membranes
TL;DR: This model together with recent structural and functional advances in the field of drug efflux provides a fairly detailed understanding of the mechanism ofDrug efflux across the two membranes.
Journal ArticleDOI
Non-equivalent roles of two periplasmic subunits in the function and assembly of triclosan pump TriABC from Pseudomonas aeruginosa
TL;DR: It is found that analogous mutations in the α‐helical hairpin and membrane proximal domains of TriA and TriB differentially affect triclosan efflux and assembly of the complex.