Jonathan L. Bramson

TL;DR: The simplest (single equation) models for tumor growth and greater immunological detail are considered and the necessity for expanding the complexity of models in order to capture the biological mechanisms the authors wish to understand is clarified.

TL;DR: AdmIL-12.1 can be used to deliver very high levels of localized cytokine production and it is confirmed that the IL-12 produced from this vector actually affects the local cytokine environment of the tumor and activates responder cells present within the tumor.

TL;DR: TNF-alpha is identified as a type 1 immunoregulatory cytokine whose primary role, different from those of other type 1 cytokines, is to keep an otherwise detrimental type 1 immune response in check.

TL;DR: This analysis is the first to demonstrate that MDSCs and specifically the CD11b(+)CD15(+) MDSC subset are increased with age, and this age‐related elevation in the frequency of M DSCs may contribute to the increased cancer incidence that occurs with age.

TL;DR: Ex vivo transfection with Ad5mIL-12 resulted in 45% long term survival in Klebsiella pneumonia, whereas no animals with Klebsialla pneumonia receiving control adenovirus survived, and treatment with anti-IFN-gamma Abs or soluble TNF receptor:Ig construct partially and completely attenuated survival benefits observed in animals receiving Ad5MIL- 12, respectively.