Jonathon M. Sullivan

TL;DR: This picture argues powerfully that, for therapy of brain ischemia and reperfusion, the concept of single drug intervention cannot be effective.

TL;DR: Observations make a compelling case that eIF-2(αP) is responsible for reperfusion-induced inhibition of protein synthesis in vulnerable neurons.

TL;DR: Ethanol exerts a strong neuroprotective effect when administered up to 4 hours after ischemia, increases expression of hypoxia-inducible factor-1&agr;, and does not promote intracerebral hemorrhage when used with thrombolytics.

TL;DR: The observations contradict hypotheses that PKR activation, loss of eIF2alpha(P) phosphatase activity, or any general increase in eIF1alpha kinase activity are responsible for reperfusion-induced phosphorylation of eif2alpha, and suggest that the mechanism may involve regulation of the availability of e IF2alpha to a kinase.

TL;DR: Results reveal that proximal elements of a known cell-survival pathway are triggered by high-dose insulin during early reperfusion and results in improvement of hippocampal structure and function.