Jose M Ferrero

TL;DR: The results of the model suggest that activation of IK-ATP alone does not quantitatively account for the observed K+ efflux in metabolically impaired cardiac myocytes, and Mechanisms other than KATP channel activation should be responsible for a significant part of the K- efflux measured in hypoxic/ischemic situations.

TL;DR: Examples of several specific applications are presented, mainly related to cardiac EP simulation and model-based image analysis, showing the potential usefulness of 3D cardiac computational modelling into clinical environments as a tool to aid in the prevention, diagnosis and treatment of cardiac diseases.

TL;DR: This work develops a family of macro finite elements amenable for solving anisotropic reaction–diffusion equations with stiff reactive terms based on a semi-implicit algorithm based on operator splitting that includes adaptive time stepping for handling the stiff reactive term.

TL;DR: An enhanced INaL appears to be an important contributor to the electrophysiological phenotype and to the dysregulation of [Ca2+]i homeostasis of failing myocytes.

TL;DR: The ability of second-generation mathematical models to analyze and explain the mechanisms involved in ischemic reentry are demonstrated, and the effect of the degree of ATP-sensitive current activation in the vulnerability to reentry is studied.