José Miguel Laínez

TL;DR: This work addresses the optimization of SC planning and design considering economical and environmental issues by developing a multi-objective MILP (moMILP), which reduces the value-subjectivity inherent to the assignment of weights in the calculation of an overall environmental impact by considering endpoint damage categories as objective function.

TL;DR: Enterprise-wide decision support applications, which have real or potential relevance to the pharmaceutical industry, are reviewed and specific attention is given to the three key phases in the life cycle of an innovative drug product, namely, product development pipeline management, capacity planning and supply chain management.

TL;DR: A model predictive control (MPC) methodology is proposed that comprises a stochastic optimization approach that incorporates uncertainty and process dynamics into enterprise wide models which also contemplate cross-functional decisions.

TL;DR: In this article, a flexible formulation approach that translates a recipe representation into the SC environment is presented for solving the design-planning challenging problem of SC networks, highlighting the potential of this approach through illustrative examples of increasing complexity, where results of traditional rigid approaches and those offered by the flexible framework are compared.

TL;DR: Three important aspects of enterprise-wide decision problems that require further research are discussed: the realistic representation of the financial components and appropriate criteria for this class of problems, strategic management of supplier and customer relationships through inventory management and option contracts, and innovative approaches to suitably value and integrate a broader range of decisions available to management.