J
Joseph E. De Larco
Researcher at National Institutes of Health
Publications - 15
Citations - 1538
Joseph E. De Larco is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Epidermal growth factor & Growth factor. The author has an hindex of 14, co-authored 15 publications receiving 1529 citations.
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Biologically active phorbol esters specifically alter affinity of epidermal growth factor membrane receptors
TL;DR: TPA (12-O-tetradecanoyl-phorbol-13-acetate) reversibly inhibits the binding of 125I-labelled epidermal growth factor to treated mouse and human cells, but does not affect the bindingof various other ligands to their membrane receptors.
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Epithelioid and fibroblastic rat kidney cell clones: epidermal growth factor (EGF) receptors and the effect of mouse sarcoma virus transformation.
TL;DR: The results show that loss of EGF binding ability correlates with expression of the murine sarcoma virus transformation, and another growth factor, multiplication stimulating activity (MSA), bound to a greater extent to the fibroblastic clones than the epithelioid clones, and its binding was not decreased by sarcomA virus transformation.
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Retinoids block phenotypic cell transformation produced by sarcoma growth factor.
TL;DR: It is established that retinoids block the action in vivo of exogenous and endogenous promoters, preventing carcinogens from producing new tumours, but do not reverse the growth of many established tumours.
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Sarcoma growth factor (SGF): specific binding to epidermal growth factor (EGF) membrane receptors.
TL;DR: The SGF isolated using DEAE‐cellulose chromatography was unable to compete in a radioimmune assay using 125I‐EGF and antibody to purified mouse submaxillary gland EGF; it also was not precipitated by anti-EGF antibody.
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Transforming growth factors (TGFs): Properties and possible mechanisms of action
George J. Todaro,Joseph E. De Larco,Charlotte M. Fryling,Patricia A. Johnson,Michael B. Sporn +4 more
TL;DR: The term "autocrine secretion" has been proposed for this type of situation where a cell secretes a hormone-like substance for which it has external cell membrane receptors and may provide a partial explanation for some aspects of tumor cell progression.