Preface. Acknowledgements. Introduction. References. List of Structures. Index of Abbreviations. Diagrams.

The Rat Brain in Stereotaxic Coordinates

抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

A science of positive subjective experience, positive individual traits, and positive institutions promises to improve quality of life and prevent the pathologies that arise when life is barren and meaningless, The exclusive focus on pathology that has dominated so much of our discipline results in a model of the human being lacking the positive features that make life worth living. Hope, wisdom, creativity, future mindedness, courage, spirituality, responsibility, and perseverance are ignored or explained as transformations of more authentic negative impulses. The 15 articles in this millennial issue of the American Psychologist discuss such issues as what enables happiness, the effects of autonomy and self-regulation, how optimism and hope affect health, what constitutes wisdom, and how talent and creativity come to fruition. The authors outline a framework for a science of positive psychology, point to gaps in our knowledge, and predict that the next century will see a science and profession that will come to understand and build the factors that allow individuals, communities, and societies to flourish.

https://psycnet.apa.org/journals/amp/55/1/5.pdf

Positive psychology: An introduction.

Co-Planar Stereotaxic Atlas of the Human Brain—3-Dimensional Proportional System: An Approach to Cerebral Imaging, J. Talairach, P. Tournoux. Georg Thieme Verlag, New York (1988), 122 pp., 130 figs. DM 268

Despite the concern that has been expressed about potential method biases, and the pervasiveness of research settings with the potential to produce them, there is disagreement about whether they really are a problem for researchers in the behavioral sciences. Therefore, the purpose of this review is to explore the current state of knowledge about method biases. First, we explore the meaning of the terms “method” and “method bias” and then we examine whether method biases influence all measures equally. Next, we review the evidence of the effects that method biases have on individual measures and on the covariation between different constructs. Following this, we evaluate the procedural and statistical remedies that have been used to control method biases and provide recommendations for minimizing method bias.

Sources of Method Bias in Social Science Research and Recommendations on How to Control It

The field of neuroscience has, after a long period of looking the other way, again embraced emotion as an important research area. Much of the progress has come from studies of fear, and especially fear conditioning. This work has pin- pointed the amygdala as an important component of the system involved in the acqui- sition, storage, and expression of fear memory and has elucidated in detail how stimuli enter, travel through, and exit the amygdala. Some progress has also been made in understanding the cellular and molecular mechanisms that underlie fear conditioning, and recent studies have also shown that the findings from experimental animals apply to the human brain. It is important to remember why this work on emotion succeeded where past efforts failed. It focused on a psychologically well-defined aspect of emo- tion, avoided vague and poorly defined concepts such as "affect," "hedonic tone," or "emotional feelings," and used a simple and straightforward experimental approach. With so much research being done in this area today, it is important that the mistakes of the past not be made again. It is also time to expand from this foundation into broader aspects of mind and behavior

http://gruberpeplab.com/3131/LeDoux_2000_Emotioncircuitbrain.pdf

Emotion Circuits in the Brain

Apa yang terjadi di otak kita untuk membuat kita merasa takut, benci, marah, dan sukacita? Apakah kita mengendalikan emosi kita, atau apakah emosi itu mengendalikan kita? Apakah hewan memiliki emosi? Bagaimana pengalaman traumatis pada masa anak-anak awal dalam mempengaruhi perilaku pada masa dewasa, walaupun kita tidak memiliki memori sadar terhadap pemngalaman itu? Dalam The Emotional Brain, Joseph LeDoux menyelidiki asal-usul emosi manusia dan menjelaskan kompleksitas evolusi sistem syaraf yang memungkinkan kita dapa bertahan hidup.


Joseph LeDoux adalah salah satu profil peniliti utama dalam emotional Intelligence karya Danierl Goleman yang merupakan penulis terkemuka di bidang neurosains. Di dalam buku The Emotional Brain yan provokatif ini, ia mengeksplorasi mekanisme otak yang mendasari emosi kita mekanisme yang baru sekarang terungkap.

The Emotional Brain

What happens in our brains to make us feel fear, love, hate, anger, joy? do we control our emotions, or do they control us? Do animals have emotions? How can traumatic experiences in early childhood influence adult behavior, even though we have no conscious memory of them? In The Emotional Brain, Joseph LeDoux investigates the origins of human emotions and explains that many exist as part of complex neural systems that evolved to enable us to survive. Unlike conscious feelings, emotions originate in the brain at a much deeper level, says LeDoux, a leading authority in the field of neural science and one of the principal researchers profiled in Daniel Goleman's Emotional Intelligence. In this provocative book, LeDoux explores the underlying brain mechanisms responsible for our emotions, mechanisms that are only now being revealed. The Emotional Brain presents some fascinating findings about our familiar yet little understood emotions. For example, our brains can detect danger before we even experience the feeling of being afraid. The brain also begins to initiate physical responses (heart palpitations, sweaty palms, muscle tension) before we become aware of an associated feeling of fear. Conscious feelings, says LeDoux, are somewhat irrelevant to the way the emotional brain works. He points out that emotional responses are hard-wired into the brain's circuitry, but the things that make us emotional are learned through experience. And this may be the key to understanding, even changing, our emotional makeup. Many common psychiatric problems - such as phobias or posttraumatic stress disorder - involve malfunctions in the way emotion systems learn and remember. Understanding how thesemechanisms normally work will have important consequences for how we view ourselves and how we treat emotional disorders.

The Emotional Brain: The Mysterious Underpinnings of Emotional Life

The contribution of the amygdala and hippocampus to the acquisition of conditioned fear responses to a cue (a tone paired with footshock) and to context (background stimuli continuously present in the apparatus in which tone-shock pairings occurred) was examined in rats. In unoperated controls, responses to the cue conditioned faster and were more resistant to extinction than were responses to contextual stimuli. Lesions of the amygdala interfered with the conditioning of fear responses to both the cue and the context, whereas lesions of the hippocampus interfered with conditioning to the context but not to the cue. The amygdala is thus involved in the conditioning of fear responses to simple, modality-specific conditioned stimuli as well as to complex, polymodal stimuli, whereas the hippocampus is only involved in fear conditioning situations involving complex, polymodal events. These findings suggest an associative role for the amygdala and a sensory relay role for the hippocampus in fear conditioning.

/pdf/differential-contribution-of-amygdala-and-hippocampus-to-4rauxwzsik.pdf

Differential Contribution of Amygdala and Hippocampus to Cued and Contextual Fear Conditioning

https://www.cell.com/neuron/pdf/S0896-6273(05)00823-8.pdf

Joseph E. LeDoux

Papers

Emotion Circuits in the Brain

The Emotional Brain

The Emotional Brain: The Mysterious Underpinnings of Emotional Life

Differential Contribution of Amygdala and Hippocampus to Cued and Contextual Fear Conditioning

Contributions of the Amygdala to Emotion Processing: From Animal Models to Human Behavior