Joseph V. Uri

TL;DR: Parenteral administration of SK&F 75073 to experimental animals resulted in high and prolonged serum levels when compared with cefazolin and other injectable cephalosporins, and this favorable serum profile was reflected in the excellent protection observed in mice infected with pathogenic bacteria.

TL;DR: The synthesis, microbiological profile and in vivo effectiveness in laboratory animals of a series of cephalosporins having 7-acyl substituents derived from methylthioacetic acid are described, and one derivative, 7-trifluoromethylthioacetamido-3-cephem-4-carboxylic acid, was found to have outstanding antibacterial activity in vitro and in vitro.

TL;DR: One derivative, 7-[R-2-amino-2-(4-hydroxyphenylglycyl)acetamido]-3-triazole-4(5)-ylthiomethyl)-3-cephem-4-carboxylic acid was found to have outstanding in vitro and in vivo activities along with oral and subcutaneous serum levels in the mouse that were significantly higher than those obtained with cephalexin.

TL;DR: The 2-aminothiazolyl-4-yl-2-alkoxyiminoacetamido substituent-containing beta-lactam antibiotics develop a stable, concentration-dependent purple or cherry-red color after reaction with sodium nitrite in acidic condition.

TL;DR: Cefatrizine had striking in vivo protective activity in mice infected with Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Hemophilus influenzae, Proteus morganii or Staphylococcus aureus reflecting its superior pharmacokinetic profile in this animal species.