J
Joshua G. A. Pinto
Researcher at McMaster University
Publications - 8
Citations - 252
Joshua G. A. Pinto is an academic researcher from McMaster University. The author has contributed to research in topics: Visual cortex & Synapsin. The author has an hindex of 6, co-authored 8 publications receiving 222 citations. Previous affiliations of Joshua G. A. Pinto include Credit Suisse.
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Developmental changes in GABAergic mechanisms in human visual cortex across the lifespan.
TL;DR: This study shows for the first time how GABAergic mechanisms develop in the human visual cortex across the lifespan, and provides key information for translating therapies developed in animal models into effective treatments for amblyopia in humans.
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Comparing development of synaptic proteins in rat visual, somatosensory, and frontal cortex.
TL;DR: A neuroinformatics approach using principal component analysis found that three components captured development of the synaptic proteins, giving the most support to an integrated network of synaptic development, but also highlight more complex patterns of development that vary in timing and end point among the cortical areas.
Journal ArticleDOI
Characterizing synaptic protein development in human visual cortex enables alignment of synaptic age with rat visual cortex.
TL;DR: In this article, the authors quantified expression of a set of highly conserved pre-and post-synaptic proteins (Synapsin, Synaptophysin, PSD-95, Gephyrin) and found that synaptic development in human primary visual cortex continues into late childhood.
Journal ArticleDOI
Effects of Fluoxetine and Visual Experience on Glutamatergic and GABAergic Synaptic Proteins in Adult Rat Visual Cortex.
Simon Beshara,Brett R. Beston,Brett R. Beston,Joshua G. A. Pinto,Joshua G. A. Pinto,Kathryn M. Murphy +5 more
TL;DR: The results suggest that fluoxetine treatment creates a novel synaptic environment dominated by GluN2A- and GABAAα1-dependent plasticity.
Effects of Fluoxetine and Visual Experience on Glutamatergic and GABAergic Synaptic Proteins
TL;DR: In this paper, the effect of fluoxetine treatment in adult rats, alone or in combination with visual deprivation [monocular deprivation (MD)] on a set of highly conserved presynaptic and postsynaptic proteins (synapsin, synaptophysin, VGLUT1, VGAT, PSD-95, gephyrin, GluN1, GLUA2, GLuN2B, GBLN2A, GABAA1,GABAA3).