J
Jr Jb Hibbs
Publications - 2
Citations - 1138
Jr Jb Hibbs is an academic researcher. The author has contributed to research in topics: Cytotoxic T cell & Citric acid cycle. The author has an hindex of 2, co-authored 2 publications receiving 1123 citations.
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Journal Article
Differentiation of murine macrophages to express nonspecific cytotoxicity for tumor cells results in L-arginine-dependent inhibition of mitochondrial iron-sulfur enzymes in the macrophage effector cells.
JC Drapier,Jr Jb Hibbs +1 more
TL;DR: It is speculated that the pattern of metabolic inhibition induced in cytotoxic activated macrophages by the L-arginine-dependent effector system causes changes in the macrophage intracellular environment that increases resistance to certain facultative and obligate intrace cellular pathogens.
Journal Article
Microbiostatic effect of murine-activated macrophages for Toxoplasma gondii. Role for synthesis of inorganic nitrogen oxides from L-arginine.
TL;DR: The synthesis of inorganic nitrogen oxides from a terminal guanidino nitrogen atom of L-arginine appears to be essential for murine cytotoxic activated macrophage mediated microbiostatic capacity for T. gondii.