Juan Carlos Castillo

TL;DR: Exogenous melatonin is able to preserve renal functional status following I/R-induced injury by increasing glutathione and reducing lipid peroxidation in the early reperfusion phase, without any apparent effect on neutrophil infiltration in the late reperfusions phase.

TL;DR: The present review summarizes the recent developments of multicomponent reactions for the synthesis of biologically active molecules containing the pyrazole moiety and covers the articles published from 2015 to date related to antibacterial, anticancer, antifungal, antioxidant, α-glucosidase and α-amylase inhibitory, anti-inflammatory, antimycobacterial, antimalarial, and miscellaneous activities of pyrazoles obtained exclusively via an MCR.

TL;DR: In this article , the synthesis of 2-oxo-2 H -chromen-7-yl 4-chlorobenzoate 3 in 94% yield by an O -acylation reaction of 7-hydroxy-2H-chromen, 2-one 1 and 4chlorobenzoyl chloride 2 using a slight excess of triethylamine in acetonitrile, heating as fast as possible to 60°C, hold time 5 min, and 600 rpm stirring speed in the Monowave 50 reactor based on conventional heating principles.

TL;DR: In this paper , boric acid was used as a catalyst in the Knoevenagel reaction of HMF derivatives and active methylene compounds to afford new 5.5-hydroxymethylfurfural derivatives containing an acrylonitrile moiety.

TL;DR: In this paper , a catalyst-free synthesis of (5-formylfuran-2-yl)methyl 4-chlorobenzoate in 71% yield by an O -acylation reaction of 5-hydroxymethylfurfural with 4chlorobenzoyl chloride using a slight excess of triethylamine in dichloromethane at 20 °C for 24 h.