J
Jukka Ylikoski
Researcher at University of Helsinki
Publications - 166
Citations - 7081
Jukka Ylikoski is an academic researcher from University of Helsinki. The author has contributed to research in topics: Inner ear & Cochlea. The author has an hindex of 42, co-authored 165 publications receiving 6839 citations. Previous affiliations of Jukka Ylikoski include Helsinki University Central Hospital & Cephalon.
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Journal ArticleDOI
Expression patterns of neurotrophin and their receptor mRNAs in the rat inner ear.
Jukka Ylikoski,Jukka Ylikoski,Ulla Pirvola,Maxim Moshnyakov,Jaan Palgi,Jaan Palgi,Urmas Arumäe,Urmas Arumäe,Mart Saarma,Mart Saarma +9 more
TL;DR: The expression patterns of NT-3 and BDNF mRNAs suggest that these neurotrophins may participate in the maintenance of mature cochleovestibular neurons and they may be involved in the survival response of injured neurons.
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Rescue of hearing, auditory hair cells, and neurons by CEP-1347/KT7515, an inhibitor of c-Jun N-terminal kinase activation.
Ulla Pirvola,Liang Xing-Qun,Jussi Virkkala,Mart Saarma,Chikara Murakata,Anna Marie Camoratto,Walton Kevin M,Jukka Ylikoski +7 more
TL;DR: The results suggest that therapeutic intervention in the JNK signaling cascade, possibly by using CEP-1347, may offer opportunities to treat inner ear injuries.
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Brain-derived neurotrophic factor and neurotrophin 3 mRNAs in the peripheral target fields of developing inner ear ganglia.
TL;DR: expression of NT-3 and BDNF mRNAs in the otic vesicle before and during the ingrowth of neurites from the statoacoustic ganglion suggests that NT- 3 or BDNF or both may serve as chemoattractants for the early nerve fibers.
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FGFR1 Is Required for the Development of the Auditory Sensory Epithelium
TL;DR: It is shown that loss-of-function mutations in mouse fibroblast growth factor receptor 1 (Fgfr1) cause a dose-dependent disruption of the organ of Corti, and that FGFR1 might have a distinct later role in intercellular signaling within the differentiating auditory sensory epithelium.
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FGF/FGFR-2(IIIb) Signaling Is Essential for Inner Ear Morphogenesis
Ulla Pirvola,Bradley Spencer-Dene,Liang Xing-Qun,Päivi Kettunen,Irma Thesleff,Bernd Fritzsch,Clive Dickson,Jukka Ylikoski +7 more
TL;DR: Genetic evidence that signaling by FGFR-2(IIIb) is critical for the morphological development of the inner ear is provided, suggesting that in contrast to mesenchymal–epithelial-based FGF10 signaling demonstrated for other organs, the innerEar seems to depend on paracrine signals that operate within the epithelium.