J
Julien Andrieu
Researcher at University of Lyon
Publications - 68
Citations - 1945
Julien Andrieu is an academic researcher from University of Lyon. The author has contributed to research in topics: Ice crystals & Sublimation (phase transition). The author has an hindex of 23, co-authored 60 publications receiving 1760 citations. Previous affiliations of Julien Andrieu include Centre national de la recherche scientifique.
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Influence of controlled nucleation by ultrasounds on ice morphology of frozen formulations for pharmaceutical proteins freeze-drying
TL;DR: In this article, an ultrasound system has been designed and applied to control the freezing step of pharmaceutical proteins in vials in order to optimize industrial freeze-drying processes of pharmaceutical protein in vial.
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Freeze drying of pharmaceuticals in vials: Influence of freezing protocol and sample configuration on ice morphology and freeze-dried cake texture
TL;DR: In this article, the mean diameters and size distributions of the ice crystals have been determined by a direct optical microscopy method in cold chamber for different freezing parameters: size and type of vials (moulded or tubing), height of filling, vial right sectional surface area, shelf loading temperature.
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A Direct Characterization Method of the Ice Morphology. Relationship Between Mean Crystals Size and Primary Drying Times of Freeze-Drying Processes
TL;DR: In this paper, a new optical direct microscopy method, based on reflected flux differences, with episcopic axial lighting, was developed to characterize the structure of a standard pharmaceutical matrix used for pharmaceutical proteins free.
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Modeling of freezing step during freeze‐drying of drugs in vials
TL;DR: A mathematical model that simulates temperature profiles during freezing process of standard pharmaceutical formulations (mannitol and BSA based) was set up in two-dimensional axsymmetric space, and the ice crystal mean sizes were semi empirically estimated from the resulting temperature profiles as mentioned in this paper.
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Optimization of the Freeze-Drying Cycle: A New Model for Pressure Rise Analysis
TL;DR: In this paper, a new physical model, named PRA model, based on elementary heat and mass balance equations and on constitutive equations expressing the elementary fluxes was proposed and validated in this study for interpreting the experimental pressure rise data.