J
Junyan Shi
Researcher at University of British Columbia
Publications - 23
Citations - 5916
Junyan Shi is an academic researcher from University of British Columbia. The author has contributed to research in topics: Chemistry & Biology. The author has an hindex of 12, co-authored 14 publications receiving 5324 citations. Previous affiliations of Junyan Shi include St. Paul's Hospital.
Papers
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Journal ArticleDOI
Enhanced enteroviral infectivity via viral protease-mediated cleavage of Grb2-associated binder 1
Haoyu Deng,Gabriel Fung,Junyan Shi,Suowen Xu,Chen Wang,Meimei Yin,Jun Hou,Jingchun Zhang,Zheng Gen Jin,Honglin Luo +9 more
TL;DR: This study demonstrated that GAB1 was proteolytically cleaved after CVB3 infection at G175 and G436 by virus‐encoded protease 2Apro, independent of caspase activation and showed that virus‐induced cleavage of G AB1 is beneficial to viral growth as the N‐terminal proteolytic product of GAB2‐associated binder 1 further enhances ERK1/2 activation and promotes viral replication.
Journal ArticleDOI
Dysferlin deficiency confers increased susceptibility to coxsackievirus-induced cardiomyopathy.
Chen Wang,Chen Wang,Jerry Wong,Jerry Wong,Gabriel Fung,Gabriel Fung,Junyan Shi,Junyan Shi,Haoyu Deng,Haoyu Deng,Jingchun Zhang,Jingchun Zhang,Pascal Bernatchez,Pascal Bernatchez,Honglin Luo,Honglin Luo +15 more
TL;DR: Dysferlin deficiency is identified as a novel host risk factor for viral myocarditis and a key mechanism by which coxsackievirus infection impairs cardiac function, leading to the development of dilated cardiomyopathy is revealed.
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Coxsackievirus infection induces a non-canonical autophagy independent of the ULK and PI3K complexes.
Yasir Mohamud,Junyan Shi,Junyan Shi,Hui Tang,Pinhao Xiang,Pinhao Xiang,Yuanchao Xue,Yuanchao Xue,Huitao Liu,Huitao Liu,Chen Seng Ng,Chen Seng Ng,Honglin Luo,Honglin Luo +13 more
TL;DR: The studies reveal that CVB3 initiates a non-canonical form of autophagy that bypasses ULK1/2 and PI3K signaling pathways to ultimately converge on PI4KIIIβ- and ATG5–ATG12–atG16L1 machinery.
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LED irradiation delays postharvest senescence in pakchoi by regulating amino acid metabolism
Fuhui Zhou,Xiaozhen Yue,Dongying Xu,Junyan Shi,Shibei Fang,Shuzhi Yuan,Aili Jiang,Jinhua Zuo,Qing Wang +8 more
TL;DR: In this article , the effect of white light-emitting diode (LED) irradiation on postharvest amino acid metabolism in pakchoi has been investigated and it was found that LED irradiation had a considerable effect on the metabolism of several amino acids (histidine, cysteine and methionine, tryptophan, glycine, serine and threonine, lysine, and arginine and proline), with glycine and serine metabolism most affected.
Journal ArticleDOI
Whole-transcriptome RNA sequencing highlights the molecular mechanisms associated with the maintenance of postharvest quality in broccoli by red LED irradiation
Zhicheng Yan,Junyan Shi,Shuzhi Yuan,Dongying Xu,Shufang Zheng,Lipu Gao,Cai Wu,Jinhua Zuo,Qing Wang +8 more
TL;DR: In this paper , a total of 20,246 differentially expressed mRNAs, 3450 differentially expressing lncRNAs (DElncRNA), and 135 DEmiRNAs were identified in the response of broccoli to LED irradiation during storage, relative to non-irradiated broccoli.