Justyna Knapik-Kowalczuk

TL;DR: Fused deposition modelling is suitable technique and polyvinyl alcohol is applicable polymer for orodispersible films preparation and transition of aripiprazole into amorphous state during film preparation using 3D printing technique is confirmed.

TL;DR: The molecular mobility and physical stability of amorphous bicalutamide, a poorly water-soluble drug widely used in prostate cancer treatment, are investigated and it is found that such systems have distinctly higher water solubility and dissolution rate in comparison to the pureAmorphous form, indicating the genuine formulation potential of the proposed approach.

TL;DR: Thorough investigation of the impact of polymeric additive on the molecular mobility of disordered FL reveals unusual, previously unreported behavior, and some transformation from unstable supersaturated concentration of investigated mixture to the different, unknown concentration of FL-PVP/VA is observed.

TL;DR: Analysis of the influence of the global molecular mobility and structural properties on the crystallization tendency of three 1,4-dihydropyridine derivatives in their supercooled states using differential scanning calorimetry (DSC) and broadband dielectric spectroscopy (BDS) techniques found that nimodipine exhibits much slower crystallization in comparison to nifedipine.

TL;DR: The article describes the preparation and characterization of 3D-printed tablets with bicalutamide obtained using two-material co-extrusion-based fused deposition modeling (FDM) which gives the opportunity to modify tablet properties in a wide range, especially the dissolution rate, by producing dosage forms with a complex design.