Gentianae Radix, the dried root and rhizoma of Gentiana lutea L (Gentianaceae), has long been used as a remedy for liver and stomach inflammation, eye troubles, etc In this paper, the gastroprotective effects of the methanol extract of Gentian root (GM) were studied using different gastric lesion models In pylorus-ligated rats, administration of GM in the duodenum suppressed gastric juice secretion and total acid output in a dose-dependent manner Oral or duodenum administration of GM showed significant protection against acute gastric ulcer induced by aspirin plus pylorus ligation, water-immersion restraint stress-induced ulcers, and gastric mucosal injury induced by ethanol Furthermore, four secoiridoid glycosides, amarogentin (A1), gentiopicroside (A2), amaroswerin (A3), and swertiamarin (A4), were obtained from Gentian root or Swertia herb, and their protective effects against stress-induced ulcers and ethanol-induced gastric mucosal injury were evaluated The doses required for 50% inhibition (ID50) of A1, A3, and A4 on stress-induced ulcers were calculated to be 576, 258, and 167 mg/kg respectively The protective effect of A2 at 250 mg/kg was 265% On ethanol-induced gastritis, 50 mg/kg of A1 and A3 showed remarkable suppressive effects (337 and 454%, respectively), and 20 mg/kg of A4 exhibited a suppressive effect (308%) The effects of A1, A3, and A4 on ethanol-induced gastric lesions were canceled by 50 mg/kg indomethacin pretreatment These results suggest that the therapeutic effects of Gentian root on gastric lesions are associated with enhanced mucosal defensive factors via the prostaglandin pathway in the cell membrane, and that secoiridoid glycosides contribute to this activity

Gastroprotective effects of bitter principles isolated from Gentian root and Swertia herb on experimentally-induced gastric lesions in rats

Veterinary Herbal Medicine: A Systems-Based Approach

Bianthrones from Senna longiracemosa

Emodin and emodinanthrone rhamnoside acetates from fruits of Rhamnus prinoides

Influence of replacing rice straw with wormwood (Artemisia montana) silage on feed intake, digestibility and ruminal fermentation characteristics of sheep

K. Hackenberg

Papers

Roentgenological studies of the effect of bitters on digestive organs