K. J. Tingey

TL;DR: In this paper, the authors investigated the effect of early growth restriction on the expression of insulin-signalling proteins in skeletal muscle in a human cohort and a rat model and found decreased expression of specific insulin signalling proteins in low-birthweight subjects compared to controls.

TL;DR: The results suggest that maternal protein restriction leads to muscle insulin resistance, and reduced expression of PKC zeta may contribute to the mechanistic basis of this resistance.

TL;DR: Pregnant undernutrition, specifically during late gestation, affects adult offspring intermediary metabolism, and, in particular, glucose-insulin homeostasis in sheep, which was unaffected by fetal number.

TL;DR: These findings show that low birth weight is associated with reduced levels of adipose insulin signalling proteins, thus providing a potential molecular framework to explain why people with low birthweight are at increased risk of developing type 2 diabetes.

TL;DR: Programming of glucose-insulin metabolism in adult sheep after maternal undernutrition Updated information and services including high-resolution figures, can be found at: http://ajpregu.org/publications/ajPregu This information is current as of December 2, 2005 .