5-Hydroxytryptophan in the prophylaxis of migraine

Based on earlier clinical experiences a group of 52 nonmigrainous depressed women were treated with 3–6mg/day pizotifene (Sandomigran-Sandoz) in order to evaluate a presumed antidepressant action. The Bunney-Hamburg behavior-rating scale was employed to quantify the results. Thirteen patients showed marked improvement and 22 patients partial improvement after three weeks' treatment. Involutional and psychoreactive depressions responded better than endogenous forms. Symptomatically, anxiety and dysphoria were significantly more favorably influenced than retardation or paranoia. No serious side effects were observed.

K Knor

Papers

[The antihistaminic Sandomigran as the treatment of choice in anxious, thin, and anorexic patients with migraine]