Describes an automated method to locate and outline blood vessels in images of the ocular fundus. Such a tool should prove useful to eye care specialists for purposes of patient screening, treatment evaluation, and clinical study. The authors' method differs from previously known methods in that it uses local and global vessel features cooperatively to segment the vessel network. The authors evaluate their method using hand-labeled ground truth segmentations of 20 images. A plot of the operating characteristic shows that the authors' method reduces false positives by as much as 15 times over basic thresholding of a matched filter response (MFR), at up to a 75% true positive rate. For a baseline, they also compared the ground truth against a second hand-labeling, yielding a 90% true positive and a 4% false positive detection rate, on average. These numbers suggest there is still room for a 15% true positive rate improvement, with the same false positive rate, over the authors' method. They are making all their images and hand labelings publicly available for interested researchers to use in evaluating related methods.

/pdf/locating-blood-vessels-in-retinal-images-by-piecewise-4lgaualy1f.pdf

Locating blood vessels in retinal images by piecewise threshold probing of a matched filter response

Blood vessels usually have poor local contrast, and the application of existing edge detection algorithms yield results which are not satisfactory. An operator for feature extraction based on the optical and spatial properties of objects to be recognized is introduced. The gray-level profile of the cross section of a blood vessel is approximated by a Gaussian-shaped curve. The concept of matched filter detection of signals is used to detect piecewise linear segments of blood vessels in these images. Twelve different templates that are used to search for vessel segments along all possible directions are constructed. Various issues related to the implementation of these matched filters are discussed. The results are compared to those obtained with other methods. >

/pdf/detection-of-blood-vessels-in-retinal-images-using-two-2lxvrugvz5.pdf

Detection of blood vessels in retinal images using two-dimensional matched filters

In the framework of computer assisted diagnosis of diabetic retinopathy, a new algorithm for detection of exudates is presented and discussed. The presence of exudates within the macular region is a main hallmark of diabetic macular edema and allows its detection with a high sensitivity. Hence, detection of exudates is an important diagnostic task, in which computer assistance may play a major role. Exudates are found using their high grey level variation, and their contours are determined by means of morphological reconstruction techniques. The detection of the optic disc is indispensable for this approach. We detect the optic disc by means of morphological filtering techniques and the watershed transformation. The algorithm has been tested on a small image data base and compared with the performance of a human grader. As a result, we obtain a mean sensitivity of 92.8% and a mean predictive value of 92.4%. Robustness with respect to changes of the parameters of the algorithm has been evaluated.

A contribution of image processing to the diagnosis of diabetic retinopathy-detection of exudates in color fundus images of the human retina

We describe an automated method to locate the optic nerve in images of the ocular fundus. Our method uses a novel algorithm we call fuzzy convergence to determine the origination of the blood vessel network. We evaluate our method using 31 images of healthy retinas and 50 images of diseased retinas, containing such diverse symptoms as tortuous vessels, choroidal neovascularization, and hemorrhages that completely obscure the actual nerve. On this difficult data set, our method achieved 89% correct detection. We also compare our method against three simpler methods, demonstrating the performance improvement. All our images and data are freely available for other researchers to use in evaluating related methods.

/pdf/locating-the-optic-nerve-in-a-retinal-image-using-the-fuzzy-491eimq7zn.pdf

Locating the optic nerve in a retinal image using the fuzzy convergence of the blood vessels

https://www.siue.edu/~sumbaug/RetinalProjectPapers/REVIEW%20ARTICLE%20Retinal%20image%20analysis%20--%20Concepts,%20applications%20and%20potential.pdf

K. Yanashima

Papers

Zero-crossing interval correction in tracing eye-fundus blood vessels