K
Kang-Hao Liang
Researcher at Academia Sinica
Publications - 3
Citations - 129
Kang-Hao Liang is an academic researcher from Academia Sinica. The author has contributed to research in topics: Protein domain & Point mutation. The author has an hindex of 1, co-authored 3 publications receiving 12 citations.
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Journal ArticleDOI
Effect of SARS-CoV-2 B.1.1.7 mutations on spike protein structure and function.
Tzu-Jing Yang,Tzu-Jing Yang,Pei-Yu Yu,Yuan-Chih Chang,Kang-Hao Liang,Hsian-Cheng Tso,Meng-Ru Ho,Wan-Yu Chen,Hsiu-Ting Lin,Han-Chung Wu,Shang-Te Danny Hsu,Shang-Te Danny Hsu +11 more
TL;DR: In this paper, the spike protein of SARS-CoV-2 was analyzed in the apo and ACE2-bound forms and three RBDs were found to be engaged in ACE2 binding.
Posted ContentDOI
Structure-activity relationships of B.1.617 and other SARS-CoV-2 spike variants
Tzu-Jing Yang,Tzu-Jing Yang,Pei-Yu Yu,Yuan-Chih Chang,Ning-En Chang,Ning-En Chang,Yu-Xi Tsai,Yu-Xi Tsai,Kang-Hao Liang,Piotr Draczkowski,Piotr Draczkowski,Bertina Lin,Yong Sheng Wang,Yong Sheng Wang,Yu-Chun Chien,Yu-Chun Chien,Kay-Hooi Khoo,Kay-Hooi Khoo,Han-Chung Wu,Shang-Te Danny Hsu,Shang-Te Danny Hsu +20 more
TL;DR: In this article, the spike protein of the Beta (B.1.1), Gamma (P.351), Delta and Kappa variants of SARS-CoV-2 was found to have significantly enhanced ACE2 binding.
Posted ContentDOI
Impacts on the structure-function relationship of SARS-CoV-2 spike by B.1.1.7 mutations
Tzu-Jing Yang,Tzu-Jing Yang,Pei-Yu Yu,Yuan-Chih Chang,Kang-Hao Liang,Hsian-Cheng Tso,Meng-Ru Ho,Wan-Yu Chen,Hsiu-Ting Lin,Han-Chung Wu,Shang-Te Danny Hsu,Shang-Te Danny Hsu +11 more
TL;DR: In this paper, the authors reported the structure of the S protein of B.1.7 in its apo-form and in the receptor ACE2-bound form, showing that all three RBDs were engaged in receptor binding.