K
Kara Doffek
Researcher at Medical College of Wisconsin
Publications - 31
Citations - 911
Kara Doffek is an academic researcher from Medical College of Wisconsin. The author has contributed to research in topics: Parathyroidectomy & Primary hyperparathyroidism. The author has an hindex of 13, co-authored 30 publications receiving 823 citations. Previous affiliations of Kara Doffek include Children's Hospital of Wisconsin.
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Journal ArticleDOI
Phosphatidylserine Regulates the Maturation of Human Dendritic Cells
TL;DR: It is suggested that PS exposure provides a sufficient signal to inhibit DC maturation and to modulate adaptive immune responses.
Journal ArticleDOI
Reoperative parathyroidectomy: an algorithm for imaging and monitoring of intraoperative parathyroid hormone levels that results in a successful focused approach.
TL;DR: It is proposed that ultrasonography and sestamibi studies should be done before all ReopPTXs; failure to localize should prompt sequential CT, MRI, and SVS until localization is achieved.
Journal Article
O6-Methylguanine-DNA Methyltransferase Promoter Hypermethylation Shifts the p53 Mutational Spectrum in Non-Small Cell Lung Cancer
TL;DR: The DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) removes mutagenic adducts from the O6 position of guanine, thereby protecting the genome against G to A transition mutations.
Journal ArticleDOI
Operative failures after parathyroidectomy for hyperparathyroidism: the influence of surgical volume.
Herbert Chen,Tracy S. Wang,Tina W.F. Yen,Kara Doffek,Elizabeth A. Krzywda,Sarah Schaefer,Rebecca S. Sippel,Stuart D. Wilson +7 more
TL;DR: Patients in the low-volume group were more likely to have a missed parathyroid gland in a normal anatomic location, and thus a higher proportion of preventable operative failures, than patients in the high- volume group.
Journal Article
Microsatellite instability at selected tetranucleotide repeats is associated with p53 mutations in non-small cell lung cancer.
Steven A. Ahrendt,P. A. Decker,Kara Doffek,B. Wang,Li-Hua Xu,Michael J. Demeure,Jin Jen,D. Sidransky +7 more
TL;DR: Primary lung cancers with microsatellite alterations at selected tetranucleotide repeats have a high frequency of p53 mutations and do not display a phenotype consistent with defects in mismatch repair, as well as primary adenocarcinomas without these alterations.