K
Karel P.M. Heirwegh
Researcher at Katholieke Universiteit Leuven
Publications - 48
Citations - 1447
Karel P.M. Heirwegh is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Bilirubin & Bile Pigments. The author has an hindex of 20, co-authored 48 publications receiving 1441 citations.
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Journal ArticleDOI
Assay and properties of digitonin-activated bilirubin uridine diphosphate glucuronyltransferase from rat liver
TL;DR: The enzyme activities found were higher than values reported in the literature for untreated or purified preparations from rat liver, and were above reported values of the maximal biliary excretion rate of bilirubin.
Journal ArticleDOI
Unconjugated Bilirubin and an Increased Proportion of Bilirubin Monoconjugates in the Bile of Patients with Gilbert's Syndrome and Crigler-Najjar Disease
TL;DR: The present findings suggest that Crigler-Najjar disease represents a more pronounced expression than Gilbert's syndrome of a common biochemical defect.
Journal ArticleDOI
Heterogeneity of bile pigment conjugates as revealed by chromatography of their anthranilate azopigments
TL;DR: Six groups of azopigments were demonstrable in preparations from bile and from icteric urine of man, and the amounts of these showed considerable variation among biological fluids.
Book ChapterDOI
Recent advances in the separation and analysis of diazo-positive bile pigments
Karel P.M. Heirwegh,Johan Fevery,Jules A. T. P. Meuwissen,J. De Groote,F. Compernolle,V J Desmet,F. P. Van Roy +6 more
Journal ArticleDOI
Glucuronic acid conjugates of bilirubin-IXα in normal bile compared with post-obstructive bile. Transformation of the 1-O-acylglucuronide into 2-, 3-, and 4-O-acylglucuronides
TL;DR: Details of procedures for the formation of chemical derivatives for g.l.c. and mass spectrometry have been deposited as Supplementary Publication SUP 50081 and the relevance of the present results with regard to previous reports on disaccharidic conjugates is discussed.