Karen A. Veverka

TL;DR: Observations are consistent with mechanisms where inhibition of aldehyde dehydrogenase by DSF in vitro involves oxidation of the active site, whereas MeDTC-SO forms a covalent adduct with the protein in vitro resulting in cessation of enzyme activity.

TL;DR: Results indicating that the expressed transfected receptor was functional and Neurotensin‐mediated inositol phosphate release is the first report of second messenger synthesis for this receptor expressed in atransfected cell line suggest that the relation between structure and function of the neurotensin receptor can be readily studied in trans infected cell lines.

TL;DR: Results of these studies indicate that MeDTC sulfone, a potential metabolite of disulfiram, is a potent, irreversible inhibitor of low Km mitochondrial ALDH.

TL;DR: A mixture of products derived photochemically from DSF with on-line microbore HPLC-continuous-flow liquid secondary ion mass spectrometry was analyzed and structurally characterize an interesting sulfine compound that inhibited ALDH.

TL;DR: The effect of MeDTC-sulfoxide upon the activity of human ALDH was examined and the interaction of the inhibitor with this enzyme by mass spectrometry was investigated.