K
Karl Egan
Researcher at University College Dublin
Publications - 20
Citations - 261
Karl Egan is an academic researcher from University College Dublin. The author has contributed to research in topics: Platelet activation & Population. The author has an hindex of 9, co-authored 20 publications receiving 181 citations. Previous affiliations of Karl Egan include Mater Misericordiae University Hospital & Royal College of Surgeons in Ireland.
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Journal ArticleDOI
Coagulation indices in very preterm infants from cord blood and postnatal samples
Elaine Neary,Naomi McCallion,Naomi McCallion,Barry Kevane,Barry Kevane,Melanie Cotter,Melanie Cotter,Karl Egan,I. Regan,Colin Kirkham,Ciaran Mooney,S Coulter-Smith,F. Ni Ainle,F. Ni Ainle +13 more
TL;DR: Very premature infants are at high risk of bleeding complications, however, few data exist on ranges for standard coagulation tests, so it is necessary to select patients suitable for bleeding complications based on prior history.
Journal ArticleDOI
Platelet Releasate Proteome Profiling Reveals a Core Set of Proteins with Low Variance between Healthy Adults.
Martin Parsons,Martin Parsons,Paulina B. Szklanna,Paulina B. Szklanna,Jose A. Guerrero,Kieran Wynne,Feidhlim Dervin,Karen O'Connell,Seamus Allen,Karl Egan,Karl Egan,Cavan Bennett,Christopher McGuigan,Cedric Gheveart,Fionnuala Ní Áinle,Patricia B. Maguire +15 more
TL;DR: Taken together, the PR contains valuable soluble and vesicular cargo and has low‐population variance among healthy adults, rendering it a potentially useful platform for diagnostic fingerprinting of platelet‐related disease.
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Plasma Thrombin Generation and Sensitivity to Activated Protein C Among Patients With Myeloma and Monoclonal Gammopathy of Undetermined Significance.
Maeve P. Crowley,Barry Kevane,Susan O'Shea,Shane Quinn,Karl Egan,Oonagh Gilligan,Fionnuala Ní Áinle +6 more
TL;DR: In this paper, the authors characterized patterns of plasma thrombin generation and sensitivity to the anticoagulant activity of activated protein C (APC) at the time of initial diagnosis of myeloma and in response to therapy in comparison to that observed among patients with MGUS and matched, healthy volunteers.
Journal ArticleDOI
Elevated venous thromboembolism risk in preeclampsia: molecular mechanisms and clinical impact
TL;DR: Evidence for the role of neutrophil extracellular traps and cell-free DNA in the pathogenesis of VTE has emerged and some evidence exists to suggest that this may be of relevance in preeclampsia.
Journal ArticleDOI
Early onset preeclampsia is associated with an elevated mean platelet volume (MPV) and a greater rise in MPV from time of booking compared with pregnant controls: results of the CAPE study.
Cathy Monteith,Karl Egan,Hugh O'Connor,Patricia B. Maguire,Barry Kevane,Paulina B. Szklanna,Sharon Cooley,Fergal D. Malone,Fergal D. Malone,Fionnuala Ní Áinle,Fionnuala Ní Áinle +10 more
TL;DR: This study did not demonstrate a potential use for increased platelet volume in patients with early onset preeclampsia and unaffected controls from time of first antenatal visit until the postpartum, and there was no significant difference during the first trimester or post partum when comparing the MPV in EOPE to controls.