K
Karnail Atwal
Researcher at Princeton University
Publications - 24
Citations - 1761
Karnail Atwal is an academic researcher from Princeton University. The author has contributed to research in topics: Aryl & Alkyl. The author has an hindex of 13, co-authored 24 publications receiving 1689 citations.
Papers
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Journal ArticleDOI
Dihydropyrimidine calcium channel blockers. 3. 3-Carbamoyl-4-aryl-1,2,3,4-tetrahydro-6-methyl-5-pyrimidinecarboxylic acid esters as orally effective antihypertensive agents.
Karnail Atwal,Brian N. Swanson,Steven E. Unger,Floyd David M,Suzanne Moreland,Anders Hedberg,Brian C. O'Reilly +6 more
TL;DR: The results demonstrate that the active R-(-)-enantiomer 20a of 7 is both more potent and longer acting than nifedipine (1) as an antihypertensive agent in the SHR.
Journal ArticleDOI
Dihydropyrimidine calcium channel blockers. 4. Basic 3-substituted-4-aryl-1,4-dihydropyrimidine-5-carboxylic acid esters. Potent antihypertensive agents.
G. C. Rovnyak,Karnail Atwal,Anders Hedberg,Kimball Sd,Suzanne Moreland,Jack Z. Gougoutas,Brian C. O'Reilly,Joseph Schwartz,Mary F. Malley +8 more
TL;DR: Dihydropyrimidine 12a is both more potent and longer acting than nifedipine and compares most favorably with the long-acting dihydropyridine derivative amlodipine in vitro and has the potential advantage of being a single enantiomer in vivo.
Journal ArticleDOI
Dihydropyrimidine calcium channel blockers: 2-heterosubstituted 4-aryl-1,4-dihydro-6-methyl-5-pyrimidinecarboxylic acid esters as potent mimics of dihydropyridines.
Karnail Atwal,Rovnyak George C,Joseph Schwartz,Suzanne Moreland,Anders Hedberg,Jack Z. Gougoutas,Mary F. Malley,David M. Floyd +7 more
TL;DR: The solid-state structure of dihydropyrimidine analogue 8g shows that these compounds can adopt a molecular conformation which is similar to the reported conformation of diHydropyridine calcium channel blockers.
Patent
Pyranyl cyanoguanidine derivatives
TL;DR: Novel compounds having the formula (See formula I) wherein R1-R9 are as described herein, are useful as antiischemic agents as discussed by the authors. But they are difficult to synthesize.
Patent
Aryl urea (thiourea) and cyanoguanidine derivatives
Karnail Atwal,Rovnyak George C +1 more
TL;DR: In this article, novel compounds useful in the treatment of ischemic conditions and arrhythmia having the formula I ##STR1## wherein X is oxygen, sulfur or NCN and the R groups are as defined herein.