K
Kathie Y. Sun
Researcher at University of North Carolina at Chapel Hill
Publications - 6
Citations - 295
Kathie Y. Sun is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Copy-number variation & Haplotype. The author has an hindex of 4, co-authored 6 publications receiving 207 citations. Previous affiliations of Kathie Y. Sun include National Institutes of Health.
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Journal ArticleDOI
Lung cancer mutation profile of EGFR, ALK, and KRAS: Meta-analysis and comparison of never and ever smokers.
TL;DR: Key driver mutations and several patient features are highly prevalent in lung cancers of never smokers, which may be helpful as patient demographic models are developed to predict successful outcomes of targeted therapeutic interventions NSCLC.
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The Ethical, Legal, and Social Implications Program of the National Human Genome Research Institute: Reflections on an Ongoing Experiment*
Jean E. McEwen,Joy T. Boyer,Kathie Y. Sun,Karen H. Rothenberg,Nicole C. Lockhart,Mark S. Guyer +5 more
TL;DR: The program's influence is likely to grow as ELSi research, genomics research, and policy development activities become increasingly integrated, and the benefits of increased integration while preserving the autonomy, objectivity, and intellectual independence of ELSI investigators presents ongoing challenges and new opportunities.
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Evolving approaches to the ethical management of genomic data.
TL;DR: The ethical landscape in the field of genomics is rapidly shifting; calls increase for the expanded use of broad or even open consent, and as controversy grows about how best to handle incidental genomic findings, approaches to the ethical management of genomic information will continue to evolve alongside the science.
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POLG2 disease variants: analyses reveal a dominant negative heterodimer, altered mitochondrial localization and impaired respiratory capacity
TL;DR: It is predicted that abnormal protein folding or aggregation or both contribute to the pathophysiology of these disorders.
Journal ArticleDOI
Bayesian modeling of skewed X inactivation in genetically diverse mice identifies a novel Xce allele associated with copy number changes.
Kathie Y. Sun,Daniel Oreper,Sarah A. Schoenrock,Rachel C. McMullan,Paola Giusti-Rodríguez,Vasyl Zhabotynsky,Darla R. Miller,Lisa M. Tarantino,Fernando Pardo-Manuel de Villena,William Valdar +9 more
TL;DR: Inter-individual variability in XCI suggests mouse epiblasts contain on average 20-30 cells contributing to brain and NOD/ShiLtJ has a novel and unique functional allele, Xcef, that is the weakest in the Xce allelic series.