K
Katy Milne
Researcher at BC Cancer Agency
Publications - 61
Citations - 4908
Katy Milne is an academic researcher from BC Cancer Agency. The author has contributed to research in topics: Immune system & Ovarian cancer. The author has an hindex of 28, co-authored 51 publications receiving 3654 citations. Previous affiliations of Katy Milne include University of Victoria.
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Journal ArticleDOI
CD20+ Tumor-Infiltrating Lymphocytes Have an Atypical CD27− Memory Phenotype and Together with CD8+ T Cells Promote Favorable Prognosis in Ovarian Cancer
Julie S. Nielsen,Rob A. Sahota,Katy Milne,Sara E. Kost,Nancy J. Nesslinger,Peter H. Watson,Brad H. Nelson +6 more
TL;DR: In high-grade serous ovarian tumors, CD20+ TIL have an antigen–experienced but atypical CD27− memory B-cell phenotype, and are uncoupled from serum autoantibodies, express markers of antigen-presenting cells, and colocalize with CD8+ T cells.
Journal ArticleDOI
Low and variable tumor reactivity of the intratumoral TCR repertoire in human cancers
Wouter Scheper,Sander Kelderman,Lorenzo F. Fanchi,Carsten Linnemann,Gavin M. Bendle,Marije A. J. de Rooij,Christian Hirt,Riccardo Mezzadra,Maarten Slagter,Krijn K. Dijkstra,Roelof J.C. Kluin,Petur Snaebjornsson,Katy Milne,Brad H. Nelson,Henry Zijlmans,Gemma G. Kenter,Emile E. Voest,John B. A. G. Haanen,Ton N. Schumacher +18 more
TL;DR: The intrinsic tumor reactivity of the intratumoral TCR repertoire of CD8+ T cells in ovarian and colorectal cancer is analyzed to indicate that the intrinsic capacity of intrumoral T cells to recognize adjacent tumor tissue can be rare and variable, and suggest that clinical efforts to reactivate intratumor T cells will benefit from approaches that simultaneously increase the quality of the intruder's TCR repertoires.
Journal ArticleDOI
Systematic Analysis of Immune Infiltrates in High-Grade Serous Ovarian Cancer Reveals CD20, FoxP3 and TIA-1 as Positive Prognostic Factors
Katy Milne,Martin Köbel,Steven E. Kalloger,Rebecca O Barnes,Dongxia Gao,C. Blake Gilks,Peter H. Watson,Peter H. Watson,Peter H. Watson,Brad H. Nelson,Brad H. Nelson,Brad H. Nelson +11 more
TL;DR: Host immune responses to EOC vary widely according to histological subtype and the extent of residual disease, and TIA-1, FoxP3 and CD20 emerge as new positive prognostic factors in high-grade serous EOC from optimally debulked patients.
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Tumor-Infiltrating Plasma Cells Are Associated with Tertiary Lymphoid Structures, Cytolytic T-Cell Responses, and Superior Prognosis in Ovarian Cancer
TL;DR: It is proposed that TLS facilitate coordinated antitumor responses involving the combined actions of cytolytic T cells and antibody-producing PCs, associated with the most robust, prognostically favorable CD8+ TIL responses in HGSC.
Journal ArticleDOI
Tumor-infiltrating lymphocytes predict response to anthracycline-based chemotherapy in estrogen receptor-negative breast cancer
Nathan R. West,Katy Milne,Pauline T. Truong,Nicol Macpherson,Brad H. Nelson,Peter H. Watson,Peter H. Watson,Peter H. Watson +7 more
TL;DR: ER-negative breast cancers with high levels of TIL have heightened sensitivity to anthracycline-based chemotherapy, as assessed by the immediate response to neoadjuvant therapy and long-term outcome following adjuvant therapy.