Carsten Linnemann

TL;DR: In this paper, the authors investigated whether tumor-specific CD4+ T-cell reactivity is a common property in human melanoma and found that it is not common in most cases.

TL;DR: This work addressed whether neo-antigen–specific CD4+ T-cell reactivity is a common property in human melanoma.

TL;DR: It is shown that lethal cytokine-driven autoimmune pathology can occur in mouse models of TCR gene therapy under conditions that closely mimic the clinical setting and it is demonstrated that adjustments in the design of gene therapy vectors and target T cell populations can be used to reduce the risk of T CR gene therapy–induced autoimmune pathology.

TL;DR: MIGEC (molecular identifier groups–based error correction), a strategy for high-throughput sequencing data analysis, allows for nearly absolute error correction while fully preserving the natural diversity of complex immune repertoires.

TL;DR: The intrinsic tumor reactivity of the intratumoral TCR repertoire of CD8+ T cells in ovarian and colorectal cancer is analyzed to indicate that the intrinsic capacity of intrumoral T cells to recognize adjacent tumor tissue can be rare and variable, and suggest that clinical efforts to reactivate intratumor T cells will benefit from approaches that simultaneously increase the quality of the intruder's TCR repertoires.