Katy Milne

TL;DR: In high-grade serous ovarian tumors, CD20+ TIL have an antigen–experienced but atypical CD27− memory B-cell phenotype, and are uncoupled from serum autoantibodies, express markers of antigen-presenting cells, and colocalize with CD8+ T cells.

TL;DR: The intrinsic tumor reactivity of the intratumoral TCR repertoire of CD8+ T cells in ovarian and colorectal cancer is analyzed to indicate that the intrinsic capacity of intrumoral T cells to recognize adjacent tumor tissue can be rare and variable, and suggest that clinical efforts to reactivate intratumor T cells will benefit from approaches that simultaneously increase the quality of the intruder's TCR repertoires.

TL;DR: Host immune responses to EOC vary widely according to histological subtype and the extent of residual disease, and TIA-1, FoxP3 and CD20 emerge as new positive prognostic factors in high-grade serous EOC from optimally debulked patients.

TL;DR: It is proposed that TLS facilitate coordinated antitumor responses involving the combined actions of cytolytic T cells and antibody-producing PCs, associated with the most robust, prognostically favorable CD8+ TIL responses in HGSC.

TL;DR: ER-negative breast cancers with high levels of TIL have heightened sensitivity to anthracycline-based chemotherapy, as assessed by the immediate response to neoadjuvant therapy and long-term outcome following adjuvant therapy.