Kay H. Wilkinson

TL;DR: In long-standing extensive ulcerative colitis, the severity of colonic inflammation is an important determinant of the risk of colorectal neoplasia and endoscopic and histological grading of inflammation could allow better risk stratification for surveillance programs.

TL;DR: Although two thirds of patients with potentially life-threatening neoplasia benefited from surveillance, the program was not wholly effective in cancer prevention, suggesting there is no need to intensify surveillance over time.

TL;DR: Surveillance identified some patients at a curable stage of cancer or with dysplasia, andLimiting factors were failure to include patients with presumed distal colitis, biennial colonoscopy, the number of biopsy specimens at each colonoscopic, and variation in histological identification and grading of Dysplasia.

TL;DR: Macroscopic colonoscopic features help predict neoplasia risk in UC and it should be possible to reduce surveillance frequency to five years in this cohort.

TL;DR: MMP-2 is controlled at the level of mRNA and protein production and activation in colorectal cancer, and active M MP-2 and MMP-9 enzymes are associated strongly with Dukes' A and C stages of the disease.