K
Kazuaki Iguchi
Researcher at University of Shizuoka
Publications - 80
Citations - 1261
Kazuaki Iguchi is an academic researcher from University of Shizuoka. The author has contributed to research in topics: Galanin & Theanine. The author has an hindex of 18, co-authored 79 publications receiving 1055 citations.
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Journal ArticleDOI
Blood brain barrier permeability of (-)-epigallocatechin gallate, its proliferation-enhancing activity of human neuroblastoma SH-SY5Y cells, and its preventive effect on age-related cognitive dysfunction in mice.
Monira Pervin,Keiko Unno,Aimi Nakagawa,Yuu Takahashi,Kazuaki Iguchi,Hiroyuki Yamamoto,Minoru Hoshino,Hara Aya,Akiko Takagaki,Fumio Nanjo,Akira Minami,Shinjiro Imai,Yoriyuki Nakamura +12 more
TL;DR: Cognitive dysfunction in mice is suppressed after ingesting GTCs when a low concentration of E GCG is incorporated into the brain parenchyma via the BBB, and the additive effect of EGC and GA suggests that EGCG sustains a preventive effect after the hydrolysis to E GC and GA.
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Blood-Brain Barrier Permeability of Green Tea Catechin Metabolites and their Neuritogenic Activity in Human Neuroblastoma SH-SY5Y Cells.
Keiko Unno,Monira Pervin,Aimi Nakagawa,Kazuaki Iguchi,Hara Aya,Akiko Takagaki,Fumio Nanjo,Akira Minami,Yoriyuki Nakamura +8 more
TL;DR: The ability of EGC-M5 to affect nerve cell proliferation and neuritogenesis suggests that EGC's conjugated forms into the blood-brain barrier may promote neurogenesis in the brain.
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Salivary secretion of highly concentrated chromogranin a in response to noradrenaline and acetylcholine in isolated and perfused rat submandibular glands.
Tomio Kanno,Naoto Asada,Haruko Yanase,Toshihiko Iwanaga,Tsuyoshi Ozaki,Yasuko Nishikawa,Kazuaki Iguchi,Tohru Mochizuki,Minoru Hoshino,Noboru Yanaihara +9 more
TL;DR: Novel evidence is provided that CgA‐like immunoreactivity (IR) is stored in the exocrine cells in the granular convoluted tubule, and is secreted into saliva by stimulation with NAd and acetylcholine (ACh) in the isolated and perfused rat submandibular gland.
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Decline in glutathione peroxidase activity is a reason for brain senescence: consumption of green tea catechin prevents the decline in its activity and protein oxidative damage in ageing mouse brain
Takahiro Kishido,Keiko Unno,Hirotoshi Yoshida,Daisuke Choba,Rie Fukutomi,Shunsuke Asahina,Kazuaki Iguchi,Naoto Oku,Minoru Hoshino +8 more
TL;DR: The results suggest that decreased activity of GPx importantly contributes to brain dysfunction in ageing SAMP10 mice and the intake of GT-catechin protected the decline in GPx activity and age-related oxidative damage in the brain.
Journal ArticleDOI
Theanine intake improves the shortened lifespan, cognitive dysfunction and behavioural depression that are induced by chronic psychosocial stress in mice.
Keiko Unno,Keisuke Fujitani,Nina Takamori,Fumiyo Takabayashi,Ken-ichi Maeda,Hideaki Miyazaki,Naoki Tanida,Kazuaki Iguchi,Kayoko Shimoi,Minoru Hoshino +9 more
TL;DR: It was found that mice began to die earlier under confront-housing than group-housed control mice, and psychosocial stress accelerates age-related alterations such as oxidative damage, lifespan, cognitive dysfunction and behavioural depression.